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Naringenin Suppresses Chemically Induced Skin Cancer in Two-Stage Skin Carcinogenesis Mouse Model
- Source :
- Nutrition and cancer. 72(6)
- Publication Year :
- 2019
-
Abstract
- Background: Naringenin, a flavonoid present in citrus fruits has many health promoting activities. It has been reported to protect skin from UV radiation, thermal damage and atopic allergies. Despite many skin protective effects, in vivo effect of naringenin on skin cancer has not been reported so far.Objective: The present work was designed to study the chemo preventive effect of naringenin on chemically induced skin cancer in mice.Methods: Two stage model of skin papillomagenesis, using DMBA plus croton oil, was used to study the effect of naringenin in Swiss albino mice. The chemo preventive effect was evaluated using morphological, histopathological and biochemical features.Results: Oral administration of naringenin reduced the skin papilloma in both pre-treatment as well as post-treatment groups of mice. The number as well as size of papilloma was significantly reduced in the treated groups. Histopathological studies showed that naringenin treatment suppressed papillomagenesis. Biochemical studies further revealed decrease in the activity of glyoxalase-1 enzyme and an increase in carbonyl content. The effect was more pronounced in ant-initiation group.Conclusion: Naringenin exhibited anti-tumor effect in two stage carcinogenesis mouse skin tumor model. This study revealed that consumption of citrus fruits and the naringenin therein may be helpful in suppression of skin cancer.
- Subjects :
- 0301 basic medicine
Naringenin
Cancer Research
Skin Neoplasms
Carcinogenesis
Croton Oil
9,10-Dimethyl-1,2-benzanthracene
Medicine (miscellaneous)
DMBA
Pharmacology
medicine.disease_cause
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Oral administration
In vivo
medicine
Animals
Croton oil
Skin Papilloma
030109 nutrition & dietetics
Nutrition and Dietetics
Chemistry
Plant Extracts
food and beverages
medicine.disease
Oncology
030220 oncology & carcinogenesis
Flavanones
Skin cancer
Subjects
Details
- ISSN :
- 15327914
- Volume :
- 72
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Nutrition and cancer
- Accession number :
- edsair.doi.dedup.....57110cf15f18d902f550cd886c241f0e