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Prenatal dioxin exposure estimated from dioxins in breast milk and sex hormone levels in umbilical cord blood in Vietnamese newborn infants
- Source :
- Science of The Total Environment. 615:1312-1318
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Dioxin concentrations remain elevated in the environment and humans residing near the former US Air Force base in Bien Hoa city, South Vietnam. We recruited 210 mother-infant pairs for whom breast milk dioxin levels were reported in our previous study. Cord blood samples were collected from 162 mother-infant pairs. We selected 16 cord blood samples with a volume over 20mL and fat content of ≥0.03g. Toxic equivalent levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (TEQ-PCDD/Fs) and concentrations of 17 congeners, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), in cord blood were measured and compared with levels in breast milk (Study 1). Levels of 2,3,7,8-TCDD and TEQ-PCDD/Fs in cord blood samples were highly and significantly correlated with those in breast milk samples in the same pairs. This suggests dioxins in breast milk reflect prenatal dioxin exposure. Estradiol (E2) and testosterone (TS) were measured in cord blood serum from 162 samples. Associations between dioxins in breast milk and cord blood sex hormones were analyzed by infant sex, after adjusting for confounding factors (Study 2). Increased levels of TEQ-PCDD/Fs in breast milk were associated with decreased cord blood TS in girls. In boys, a significant reduction of cord blood TS was observed in those exposed to 2,3,7,8-TCDD at high levels (≥5.5pg/g lipid). There was no significant association between E2 and dioxins in breast milk in either sex. These results suggest increased prenatal dioxin exposure is associated with decreased cord TS, but in boys, only high level of 2,3,7,8-TCDD influence cord blood TS.
- Subjects :
- Male
0301 basic medicine
Environmental Engineering
Cord
Polychlorinated dibenzodioxins
Physiology
010501 environmental sciences
Breast milk
Dioxins
01 natural sciences
Umbilical cord
Toxicology
03 medical and health sciences
chemistry.chemical_compound
Sex hormone-binding globulin
medicine
Humans
Environmental Chemistry
Testosterone
Gonadal Steroid Hormones
Waste Management and Disposal
0105 earth and related environmental sciences
Estradiol
Milk, Human
biology
Chemistry
Fetal Blood
Pollution
030104 developmental biology
medicine.anatomical_structure
Vietnam
Maternal Exposure
Cord blood
biology.protein
Environmental Pollutants
Female
Polychlorinated dibenzofurans
Subjects
Details
- ISSN :
- 00489697
- Volume :
- 615
- Database :
- OpenAIRE
- Journal :
- Science of The Total Environment
- Accession number :
- edsair.doi.dedup.....56f409f82aec2da9d2ada21814aa846d