Back to Search
Start Over
Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease
- Source :
- Repositorio Abierto de la UdL, Universitad de Lleida, Aging (Albany NY), UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), Aging-US, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, AGING-US, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
- Publication Year :
- 2021
- Publisher :
- Impact Journals, 2021.
-
Abstract
- This study assessed the association of CD5L and soluble CD36 (sCD36) with the risk of a cardiovascular event (CVE), including CV death and all-cause mortality in CKD. We evaluated the association of CD5L and sCD36 with a predefined composite CV endpoint (unstable angina, myocardial infarction, transient ischemic attack, cerebrovascular accident, congestive heart failure, arrhythmia, peripheral arterial disease [PAD] or amputation by PAD, aortic aneurysm, or death from CV causes) and all-cause mortality using Cox proportional hazards regression, adjusted for CV risk factors. The analysis included 1,516 participants free from pre-existing CV disease followed up for 4 years. The median age was 62 years, 38.8% were female, and 26.8% had diabetes. There were 98 (6.5%) CVEs and 72 (4.8%) deaths, of which 26 (36.1%) were of CV origin. Higher baseline CD5L concentration was associated with increased risk of CVE (HR, 95% CI, 1.17, 1.0-1.36), and all-cause mortality (1.22, 1.01-1.48) after adjusting for age, sex, diabetes, systolic blood pressure, dyslipidemia, waist circumference, smoking, and CKD stage. sCD36 showed no association with adverse CV outcomes or mortality. Our study showed for the first time that higher concentrations of CD5L are associated with future CVE and all-cause mortality in individuals with CKD. This research was supported by grants from the European Foundation for the Study of Diabetes (2014-EFSD-00914) Düsseldorf, Germany; the European Regional Development Fund; and the Carlos III National Institute of Health (PI14/1772) Madrid, Spain. CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM) and CIBER on Liver and Digestive Diseases (CIBEREHD) are an initiative of ISCIII, Madrid, Spain. The NEFRONA study is funded by a research grant from AbbVie, Lake County, Illinois.
- Subjects :
- Male
Aging
Cardiovascular system--Diseases
Informàtica::Automàtica i control [Àrees temàtiques de la UPC]
PROGRESSION
030204 cardiovascular system & hematology
GLOMERULAR-FILTRATION-RATE
0302 clinical medicine
Risk Factors
Sistema cardiovascular--Malalties
Cause of Death
Chronic kidney disease
AIM
Myocardial infarction
MACROPHAGES
RISK
Receptors, Scavenger
0303 health sciences
APOPTOSIS INHIBITOR
Biochemical markers
Middle Aged
3. Good health
Cardiovascular Diseases
Marcadors bioquímics
Cardiology
Female
SOLUBLE CD36
Research Paper
medicine.medical_specialty
Ciències de la salut::Medicina [Àrees temàtiques de la UPC]
Renal function
PLASMA SCD36
CD5L
Cardiovascular events
03 medical and health sciences
cardiovascular events
Kidneys--Diseases
Internal medicine
Diabetes mellitus
medicine
Mortalitat
Humans
Renal Insufficiency, Chronic
Mortality
030304 developmental biology
Aged
business.industry
Unstable angina
Cell Biology
medicine.disease
sCD36
mortality
Blood pressure
ATHEROSCLEROSIS
Gene Expression Regulation
Heart failure
3121 General medicine, internal medicine and other clinical medicine
Ronyons--Malalties
1182 Biochemistry, cell and molecular biology
business
Apoptosis Regulatory Proteins
Dyslipidemia
chronic kidney disease
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 19454589
- Database :
- OpenAIRE
- Journal :
- Repositorio Abierto de la UdL, Universitad de Lleida, Aging (Albany NY), UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), Aging-US, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, AGING-US, r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
- Accession number :
- edsair.doi.dedup.....56ed12280cc69ea81a614108900cf04e