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Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects
- Source :
- Journal of Infectious Diseases, 190(1), 53-62. Oxford University Press, Fachiroh, J, Schouten, T, Hariwiyanto, B, Paramita, D K, Harijadi, A, Haryana, S M, Ng, M H & Middeldorp, J M 2004, ' Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma : a comparison of Indonesian, Chinese, and European subjects ', Journal of Infectious Diseases, vol. 190, no. 1, pp. 53-62 . https://doi.org/10.1086/421245
- Publication Year :
- 2003
-
Abstract
- Epstein-Barr virus (EBV)-specific immunoblot analysis was used to reveal the molecular diversity of immunoglobulin (Ig) G and IgA antibody responses against Epstein-Barr nuclear antigen (EBNA), early antigen (EA), and viral capsid antigen (VCA) in serum samples from patients with nasopharyngeal carcinoma (NPC) and control subjects, by use of immunofluorescence assay (IFA). Control donors (n=150) showed IgG responses to few EBV proteins--VCA-p18, VCA-p40, EBNA1, and Zebra--and sporadically weak IgA reactivity to EBNA1 and VCA-p18. Patients with NPC stage 1 (n=6) had similar response patterns. Patients with NPC stage 2-4 (n=132) showed significantly more diverse IgG and IgA responses to EA and VCA proteins--VCA-p18/-p40, EBNA1, Z-encoded broadly reactive activator, and EAd-p47/54, -DNAse, -thymidine kinase, and -p138. No correlation was found between IFA titers and the number of EBV proteins recognized by IgG or IgA. Our results reveal dissimilarity between EBV polypeptides recognized by IgG and IgA antibodies, which suggests independent B cell triggering events.
- Subjects :
- Immunoglobulin A
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Nasopharyngeal neoplasm
Enzyme-Linked Immunosorbent Assay
medicine.disease_cause
Immunofluorescence
Antibodies, Viral
Immunoglobulin G
White People
Antigen
Asian People
hemic and lymphatic diseases
medicine
otorhinolaryngologic diseases
Immunology and Allergy
Humans
Antigens, Viral
biology
medicine.diagnostic_test
Carcinoma
Genetic Variation
Nasopharyngeal Neoplasms
medicine.disease
Virology
Epstein–Barr virus
Europe
stomatognathic diseases
Infectious Diseases
Nasopharyngeal carcinoma
Epstein-Barr Virus Nuclear Antigens
Indonesia
Immunology
biology.protein
Hong Kong
Capsid Proteins
Antibody
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 190
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....56ec6caa8ae6b9e68b3613de4cfb2be8