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Clinical Survey of Dengue Virus Circulation in the Republic of Djibouti between 2011 and 2014 Identifies Serotype 3 Epidemic and Recommends Clinical Diagnosis Guidelines for Resource Limited Settings
- Source :
- PLoS Neglected Tropical Diseases, Vol 10, Iss 6, p e0004755 (2016), PLoS Neglected Tropical Diseases
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Dengue virus is endemic globally, throughout tropical and sub-tropical regions. While the number of epidemics due to the four DENV serotypes is pronounced in East Africa, the total number of cases reported in Africa (16 million infections) remained at low levels compared to Asia (70 million infections). The French Armed forces Health Service provides epidemiological surveillance support in the Republic of Djibouti through the Bouffard Military hospital. Between 2011 and 2014, clinical and biological data of suspected dengue syndromes were collected at the Bouffard Military hospital and analyzed to improve Dengue clinical diagnosis and evaluate its circulation in East Africa. Examining samples from patients that presented one or more Dengue-like symptoms the study evidenced 128 Dengue cases among 354 suspected cases (36.2% of the non-malarial Dengue-like syndromes). It also demonstrated the circulation of serotypes 1 and 2 and reports the first epidemic of serotype 3 infections in Djibouti which was found in all of the hospitalized patients in this study. Based on these results we have determined that screening for Malaria and the presence of the arthralgia, gastro-intestinal symptoms and lymphopenia < 1,000cell/ mm3 allows for negative predictive value and specificity of diagnosis in isolated areas superior to 80% up to day 6. This study also provides evidence for an epidemic of Dengue virus serotype 3 previously not detected in Djibouti.<br />Author Summary Dengue virus is emerging worldwide, however, little is known about the burden of Dengue in Africa. Effectively, only sporadic cases and few epidemics have been reported in the last 30 years. This descriptive study reports clinical and biological data of Dengue-suspected cases analyzed in the Bouffard military hospital of Djibouti from 2011–2014. It also confirms the circulation of Dengue virus serotypes 1 and 2 and reports the first epidemic of Dengue virus serotype 3 infections in Djibouti. Directions for diagnosis are offered to practitioners working in resource limited settings and dealing with a Dengue-like syndrome of less than seven days and negative for malaria.
- Subjects :
- Serotype
RNA viruses
Viral Diseases
Physiology
Suspected dengue
Fevers
Dengue virus
medicine.disease_cause
Pathology and Laboratory Medicine
Communicable Diseases, Emerging
Dengue fever
Geographical Locations
Dengue
White Blood Cells
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
030212 general & internal medicine
Lymphocytes
lcsh:Public aspects of medicine
Hematology
Arthralgia
Body Fluids
Infectious Diseases
Blood
Medical Microbiology
Arboviral Infections
Viral Pathogens
Viruses
Djibouti
RNA, Viral
Pathogens
Cellular Types
Anatomy
Research Article
Platelets
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
Immune Cells
030231 tropical medicine
Immunology
Microbiology
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Environmental health
Lymphopenia
medicine
East africa
Pain Management
Humans
Lymphocyte Count
Serotyping
Microbial Pathogens
Blood Cells
Biology and life sciences
Flaviviruses
business.industry
Platelet Count
Public Health, Environmental and Occupational Health
Organisms
lcsh:RA1-1270
Cell Biology
Dengue Virus
medicine.disease
Virology
Clinical diagnosis
People and Places
Africa
business
Limited resources
Malaria
Subjects
Details
- Language :
- English
- ISSN :
- 19352735 and 19352727
- Volume :
- 10
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....56e69e3a07c245d91be6e55aca66329c