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The Effect of Omega-3 Supplementation on Serum Levels of Inflammatory Biomarkers and Albumin in Hemodialysis Patients: A Systematic Review and Meta-analysis
- Source :
- Journal of Renal Nutrition. 30:182-188
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- This systematic review and meta-analysis were performed to evaluate the effect of omega-3 supplementation on serum levels of inflammatory biomarkers (C-reactive protein [CRP], high-sensitivity CRP [hs-CRP], tumor necrosis factor-alpha, interleukin-6) and albumin in patients on hemodialysis. A literature search was performed in MEDLINE, Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Web of Science, and Google Scholar. Randomized controlled trials that evaluated the effect of omega-3 supplementation versus placebo were selected. Eight randomized controlled trials comprising 371 patients on hemodialysis were included. According to our results, omega-3 supplementation significantly decreased serum levels of CRP (standardized mean difference [SMD]: -1.95 mg/Dl; 95% confidence interval [CI]: -3.09, -0.80) and hs-CRP (SMD: -2.09; 95% CI: -3.62, -0.56) but did not significantly improve albumin (SMD: 0.91; 95% CI: -0.78, 2.59), tumor necrosis factor-alpha (SMD: -1.51; 95% CI: -3.24, 0.22), and interleukin-6 (SMD: 0.72, 95% CI: -0.56, 1.99). We concluded that omega-3 supplementation leads to a significant decrease in serum levels of CRP and hs-CRP.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
030232 urology & nephrology
Medicine (miscellaneous)
Placebo
Gastroenterology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Renal Dialysis
law
Internal medicine
medicine
Humans
Inflammation
030109 nutrition & dietetics
Nutrition and Dietetics
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Albumin
Inflammatory biomarkers
Confidence interval
C-Reactive Protein
Nephrology
Strictly standardized mean difference
Meta-analysis
Dietary Supplements
Hemodialysis
business
Biomarkers
Subjects
Details
- ISSN :
- 10512276
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Journal of Renal Nutrition
- Accession number :
- edsair.doi.dedup.....56e54324cfc2d5e8b73a9cde8089b43d