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Comparison of the outcomes of stereotactic body radiotherapy versus surgical treatment for elderly (≥70) patients with early-stage non-small cell lung cancer after propensity score matching
- Source :
- Radiation Oncology (London, England), Radiation Oncology, Vol 14, Iss 1, Pp 1-11 (2019)
- Publication Year :
- 2019
- Publisher :
- BioMed Central, 2019.
-
Abstract
- Background The optimal treatment for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains inconclusive. Previous studies have shown that stereotactic body radiotherapy (SBRT) provides encouraging local control though higher incidence of toxicity in elderly than younger populations. The objective of this study was to compare the outcomes of SBRT and surgical treatment in elderly patients with clinical stage I-II NSCLC. Methods This retrospective analysis included 205 patients aged ≥70 years with clinical stage I NSCLC who underwent SBRT or surgery at Zhejiang Cancer Hospital (Hangzhou, China) from January 2012 to December 2017. A propensity score matching analysis was performed between the two groups. In addition, we compared outcomes and related toxicity in both study arms. Results Each group included 35 patients who met the inclusion criteria. Median follow-up was 50.1 (0.8–74.4) months for surgery and 35.5 (11.5–71.4) months for SBRT. The rate of cancer-specific survival was similar between the two treatment arms (p = 0.958). In patients who underwent surgery, the corresponding 3- and 5-year cancer-specific survival rates were 85.3 and 81.7%, respectively. In those who received radiotherapy, these rates were 91.3 and 74.9%, respectively. Moreover, the 3- and 5-year locoregional control in patients who underwent surgery were 90.0 and 80.0%, respectively. In those who received radiotherapy, these rates were 91.1 and 84.1%, respectively. Notably, the observed differences in progression-free survival were not statistically significant (p = 0.934). In the surgery group, grade 1–2 complications were observed in eleven patients (31%). One patient died due to perioperative infection within 30 days following surgery. There was no grade 3–5 toxicity observed in the SBRT group. Conclusions The outcomes of surgery and SBRT in elderly patients with early-stage NSCLC were similar.
- Subjects :
- lcsh:Medical physics. Medical radiology. Nuclear medicine
Male
medicine.medical_specialty
Radical resection of lung cancer
Comparative Effectiveness Research
Lung Neoplasms
Stereotactic body radiotherapy
lcsh:R895-920
medicine.medical_treatment
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Radiosurgery
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
medicine
Prevalence
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Lung cancer
Propensity Score
Aged
Retrospective Studies
Aged, 80 and over
Toxicity
business.industry
Incidence (epidemiology)
Research
Cancer
Early-stage non-small cell lung cancer
Perioperative
Advanced age
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Small Cell Lung Carcinoma
Surgery
Radiation therapy
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Propensity score matching
Female
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 1748717X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology (London, England)
- Accession number :
- edsair.doi.dedup.....56dd95f662c81c56f8f31f88a5dd75f7