Lymphocyte deactivation by (potential immunosuppressant) alkylating metabolites of cyclophosphamide

Authors :: Marlies M. Dröge
Frances W. J. Beck
Robert F. Struck
Michael W. Whitehouse
Source :: Agents and Actions. 4:117-124
Publication Year :: 1974
Publisher :: Springer Science and Business Media LLC, 1974.
Abstract: The potential immunosuppressant activity of the following compounds derived from cyclophosphamide (CPA) was evaluated: 8 known metabolites, oxidation products and hydrolytic products of CPA containing the mustard moiety; the mixture of alkylating products formed from CPA by chemical and biological oxidation in vitro; acrolein. Mechlorethamine (HN2) and mannomustine were included in this survey as reference compounds.

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