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Is the Real Prevalence of Pancreatic Neuroendocrine Tumors Underestimated? A Retrospective Study on a Large Series of Pancreatic Specimens
- Publication Year :
- 2019
- Publisher :
- S. Karger AG, 2019.
-
Abstract
- Background/Aims: The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. The aim of this study was to determine the frequency of incidental histological diagnosis of PanNET in pancreatic specimen evaluation for a purpose other other than PanNET diagnosis. Methods: One thousand seventy-four histopathological examinations of pancreatic specimens performed in 3 centers in Italy were retrospectively reviewed. All cases with a main pathological diagnosis of PanNET were excluded. Results: An incidental associated diagnosis of PanNET was made in 41 specimens (4%). Among those 41 cases, 29 (71%) had a largest diameter p = 0.048). There was no association between incidental diagnosis of PanNET and age, gender, BMI, smoking habit, diabetes, and type of operation. Conclusions: The frequency of incidental histological diagnosis of PanNET is considerably high, suggesting that their real prevalence is probably underestimated. The present study suggests a possible correlation between the incidental occurrence of PanNET and IPMN.
- Subjects :
- Adult
Male
medicine.medical_specialty
Histology
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Neuroendocrine tumors
Annual incidence
030218 nuclear medicine & medical imaging
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Endocrinology
Pancreatic neuroendocrine tumor
Internal medicine
Histological diagnosis
medicine
Prevalence
Humans
Maximum size
Incidental diagnosi
Incidental diagnosis
Pathological
Aged
Biological Specimen Banks
Retrospective Studies
Aged, 80 and over
Incidental Findings
Endocrine and Autonomic Systems
business.industry
Incidence
Large series
Retrospective cohort study
Middle Aged
medicine.disease
Pancreatic Neoplasms
Neuroendocrine Tumors
Italy
Female
Radiology
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....56c2788a2fc725dde87431ff02a4e997