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EXPOSURE TO ENVIRONMENTAL TOBACCO SMOKE INDUCES ANGIOGENESIS AND LEUKOCYTE TRAFFICKING IN LUNG MICROVESSELS
- Source :
- Experimental Lung Research. 35:119-135
- Publication Year :
- 2009
- Publisher :
- Informa UK Limited, 2009.
-
Abstract
- Exposure to environmental tobacco smoke (ETS) is known to contribute to and exacerbate inflammatory diseases of the lung such as chronic obstructive pulmonary disease (COPD) and asthma. The effect of ETS on angiogenesis and leukocyte recruitment, both of which promote lung inflammation, was investigated using lung tissue from mice exposed to aged and diluted sidestream cigarette smoke or fresh air for 12 weeks and transplanted into dorsal skin-fold chambers in nude mice. Lung tissue from mice exposed to cigarette smoke for 12 weeks exhibited significantly increased vascular density (angiogenesis) associated with selectin-mediated increased intravascular leukocyte rolling and adhesion compared to fresh air–exposed lung tissue by intravital microscopy. Further, neutrophils from nicotine-exposed mice displayed significantly increased rolling and adhesion compared to control neutrophils in microvessels of nicotine-exposed lungs versus control lung microvessels, suggesting that nicotine in cigarette smoke can augment leukocyte-endothelial interactions. ETS-induced angiogenesis and leukocyte trafficking may play a key role in airway recruitment of inflammatory cells in ETS-associated disorders such as COPD bronchitis or asthma.
- Subjects :
- Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Neutrophils
Angiogenesis
Clinical Biochemistry
Leukocyte Rolling
Article
Tobacco smoke
Nicotine
Mice
Leukocyte Trafficking
Cell Adhesion
Leukocytes
medicine
Animals
Lung
Molecular Biology
Inflammation
COPD
Neovascularization, Pathologic
business.industry
respiratory system
medicine.disease
respiratory tract diseases
Chemotaxis, Leukocyte
medicine.anatomical_structure
Microvessels
Immunology
Tobacco Smoke Pollution
business
Intravital microscopy
medicine.drug
Subjects
Details
- ISSN :
- 15210499 and 01902148
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Experimental Lung Research
- Accession number :
- edsair.doi.dedup.....56c1671828e67109068b56ceb8099c2b