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SERUM-MEDIATED LEUKEMIA CELL DESTRUCTION IN AKR MICE
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 1973
- Publisher :
- Rockefeller University Press, 1973.
-
Abstract
- AKR mice with spontaneous leukemia were infused with normal serum from a variety of species. Leukemia cell destruction was produced by serum from strains of mice possessing the full spectrum of complement components, but not by serum from strains with a genetically determined deficiency of C5. Serum from guinea pigs, horses, and humans also causes destruction of leukemia cells. The antileukemic factor in normal serum was heat labile (56°C for 35 min) and could be inactivated by cobra venom factor (CVF). Tests of individual complement factors from guinea pig serum and from human serum suggest that C5 is the antileukemic complement component in normal serum. Evidence was obtained that complement also plays a role in the antileukemic effect of interferon and endotoxin.
- Subjects :
- Antigen-Antibody Complex
Guinea Pigs
Immunology
Spleen
Caviidae
Article
Guinea pig
Mice
Mice, Inbred AKR
Species Specificity
Interferon
medicine
Animals
Humans
Immunology and Allergy
Horses
Cell destruction
Complement (group theory)
Leukemia, Experimental
biology
Venoms
Immune Sera
Complement System Proteins
medicine.disease
biology.organism_classification
Endotoxins
Disease Models, Animal
Leukemia
medicine.anatomical_structure
Interferons
Lymph Nodes
medicine.drug
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 138
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....56b915281bea54707f853c513b2fc05f