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Transition metal-free synthesis of quinolino[2′,3′3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones via cascade dehydrogenation and intramolecular N-arylation

Authors :
Hoda Hamidi
Morteza Shiri
Majid M. Heravi
Atefeh Nejatinezhad-Arani
Suhas A. Shintre
Neil A. Koorbanally
Mohammad Ali Zolfigol
Zahra Tanbakouchian
Publication Year :
2020
Publisher :
figshare, 2020.

Abstract

2-(2-Chloroquinolin-3-yl)-3-(arylamino)2,3-dihydroquinazolin-4(1H)-one was converted to quinolino[2′,3′:3,4]pyrazolo[5,1-b]quinazolin-8(6H)-ones in the presence of KOtBu in DMSO at room temperature. The present method has the advantages of easy conditions, construction of highly novel five heterocycles, transition metalfree conditions, cascade dehydrogenation and intramolecular N-arylation and good to high yield of products.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....56abc5a494e49117a368683b524916d6
Full Text :
https://doi.org/10.6084/m9.figshare.13330967