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A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression
- Source :
- BioMed Research International, BioMed Research International, Vol 2021 (2021)
- Publication Year :
- 2021
-
Abstract
- Objective. This study is aimed at investigating the enriched functions of polymeric immunoglobulin receptor (PIGR) and its correlations with liver fibrosis stage. Methods. PIGR mRNA expression in normal liver, liver fibrosis, hepatic stellate cells (HSCs), and hepatitis virus infection samples was calculated in Gene Expression Omnibus (GEO) and Oncomine databases. Enrichment analysis of PIGR-related genes was conducted in Metascape and Gene Set Enrichment Analysis (GSEA). Logistic model and ROC curve were performed to evaluate the correlations between pIgR and liver fibrosis. Results. PIGR mRNA was upregulated in advanced liver fibrosis, cirrhosis compared to normal liver (all p < 0.05 ). PIGR mRNA was also overexpressed in activated HSCs compared to senescent HSCs, liver stem/progenitor cells, and reverted HSCs (all p < 0.05 ). Enrichment analysis revealed that PIGR-related genes involved in the defense response to virus and interferon (IFN) signaling. In GEO series, PIGR mRNA was also upregulated by hepatitis virus B, C, D, and E infection (all p < 0.05 ). After adjusting age and gender, multivariate logistic regression models revealed that high PIGR in the liver was a risk factor for liver fibrosis ( OR = 82.2 , p < 0.001 ). The area under curve (AUC), positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity of PIGR for liver fibrosis stage >2 were 0.84, 0.86, 0.7, 0.61, and 0.90. Conclusion. PIGR was correlated with liver fibrosis and might involve in hepatitis virus infection and HSC transdifferentiation.
- Subjects :
- 0301 basic medicine
Liver Cirrhosis
Hepatitis B virus
Cirrhosis
Article Subject
Biology
behavioral disciplines and activities
General Biochemistry, Genetics and Molecular Biology
Virus
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Interferon
medicine
Hepatic Stellate Cells
Humans
RNA, Messenger
Progenitor cell
General Immunology and Microbiology
Transdifferentiation
Receptors, Polymeric Immunoglobulin
Computational Biology
General Medicine
medicine.disease
Hepatitis B
030104 developmental biology
Logistic Models
Gene Expression Regulation
Liver
030220 oncology & carcinogenesis
Hepatic stellate cell
Cancer research
Disease Progression
Medicine
Polymeric immunoglobulin receptor
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 23146141
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- BioMed research international
- Accession number :
- edsair.doi.dedup.....56a1f503059ca888e439913d7cdb7ba7