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Synthesis and Spectroscopic Properties of Fluorinated Coumarin Lysine Derivatives
- Source :
- The Journal of organic chemistry. 83(8)
- Publication Year :
- 2018
-
Abstract
- The site-selective incorporation of fluorescent amino acids into proteins has emerged as a valuable alternative to expressible protein reporters. For successful application, a robust and scalable, yet flexible, route to non-natural amino acids is required. This work describes an improved synthesis of coumarin-conjugated lysine derivatives where fluorinated variants are accessed. These analogues can be utilized at low pH and should find application probing biological processes that operate under acidic conditions.
- Subjects :
- chemistry.chemical_classification
Halogenation
010405 organic chemistry
Chemistry
Lysine
Spectrum Analysis
Organic Chemistry
Chemistry Techniques, Synthetic
Hydrogen-Ion Concentration
010402 general chemistry
Coumarin
01 natural sciences
Fluorescence
Combinatorial chemistry
0104 chemical sciences
Amino acid
chemistry.chemical_compound
Coumarins
Spectrum analysis
Subjects
Details
- ISSN :
- 15206904
- Volume :
- 83
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The Journal of organic chemistry
- Accession number :
- edsair.doi.dedup.....569e4c5232a31adef51cb5e85cda90ca