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An efficient fluoride-mediated O-arylation of sterically hindered halophenols with silylaryl triflates under mild reaction conditions
- Source :
- Tetrahedron Letters. 52(22):2849-2852
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- The reaction between 2,6-dihalophenols and 2-(trimethylsilyl)aryl triflates in the presence of CsF using acetonitrile as solvent at room temperature led to the formation of functionalized diaryl ethers in very good yields.
- Subjects :
- Steric effects
Functionalized diaryl ethers
Trimethylsilyl
Aryl
Organic Chemistry
Ether
O-Arylation
Aryne
Medicinal chemistry
Benzyne chemistry
Biochemistry
Solvent
chemistry.chemical_compound
Silylaryl triflates
chemistry
Drug Discovery
Organic chemistry
Acetonitrile
Mild reaction conditions
Fluoride
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 52
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi.dedup.....569ae1d2a2a41e20a67a25224482af30
- Full Text :
- https://doi.org/10.1016/j.tetlet.2011.03.124