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Cerebral white matter lesions, subjective cognitive failures, and objective neurocognitive functioning: A follow-up study in women after hypertensive disorders of pregnancy
- Source :
- Journal of Clinical and Experimental Neuropsychology, 38(5), 585-598. Taylor & Francis Group, Postma, I R, Bouma, A, De Groot, J C, Aukes, A M, Aarnoudse, J G & Zeeman, G G 2016, ' Cerebral white matter lesions, subjective cognitive failures, and objective neurocognitive functioning : A follow-up study in women after hypertensive disorders of pregnancy ', Journal of Clinical and Experimental Neuropsychology, vol. 38, no. 5, pp. 585-598 . https://doi.org/10.1080/13803395.2016.1143453, Journal of Clinical and Experimental Neuropsychology, 38(5), 585-598. Taylor and Francis Ltd.
- Publication Year :
- 2016
-
Abstract
- OBJECTIVE: Hypertensive disorders of pregnancy, like preeclampsia, are a leading cause of maternal and fetal morbidity/mortality worldwide. Preeclampsia can be complicated by the occurrence of convulsions (eclampsia). Women who experienced (pre)eclampsia more frequently report daily cognitive failures and showed increased emotional dysfunction several years later, but are not impaired on objective neurocognitive testing. In addition, women with preterm preeclampsia more often have cerebral white matter lesions (WML) on follow-up. We aimed to determine whether WML presence is related to cognitive dysfunction, anxiety, and depressive symptoms in (pre)eclamptic women.METHOD: Forty-one eclamptic, 49 preeclamptic, and 47 control women who had a normotensive pregnancy completed the Cognitive Failures Questionnaire (CFQ), the Hospital Anxiety and Depression Scale (HADS), and a broad neurocognitive test battery (visual perception and speed of information processing, motor functions, working memory, long-term memory, attention, and executive functioning). All underwent cerebral magnetic resonance imaging (MRI), and WML presence was recorded. Median elapsed time since index pregnancy was 6 years. Average age was 40 years.RESULTS: WML were more prevalent in women who had experienced preterm (pre)eclampsia (CONCLUSION: Formerly (pre)eclamptic women report cognitive dysfunction, but do not exhibit overt cognitive impairment when objectively tested on average 6 years following their pregnancy. The presence of WML is not related to objective nor to subjective cognitive impairment, anxiety, and depressive symptoms. Longitudinal studies are needed to study whether the presence of WML is a risk factor for developing objective cognitive impairment in the long term.
- Subjects :
- Pediatrics
Neuropsychological Tests
Anxiety
Hospital Anxiety and Depression Scale
ROTTERDAM-SCAN
0302 clinical medicine
POSTTRAUMATIC-STRESS-DISORDER
Pre-Eclampsia
Pregnancy
Surveys and Questionnaires
White matter hyperintensities
Eclampsia
Depression (differential diagnoses)
Cerebral Cortex
RISK
030219 obstetrics & reproductive medicine
Depression
Middle Aged
White Matter
Clinical Psychology
HYPERINTENSITIES
Neurology
Hypertension
Female
medicine.symptom
Psychology
Adult
medicine.medical_specialty
Statistics, Nonparametric
CLASSIFICATION
Preeclampsia
03 medical and health sciences
medicine
Humans
Psychiatry
Neurocognition
Retrospective Studies
Psychiatric Status Rating Scales
Memory Disorders
Recognition, Psychology
medicine.disease
Hyperintensity
LIFE
REGIONAL-DISTRIBUTION
Neurology (clinical)
Cognition Disorders
Neurocognitive
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 13803395
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical and Experimental Neuropsychology, 38(5), 585-598. Taylor & Francis Group, Postma, I R, Bouma, A, De Groot, J C, Aukes, A M, Aarnoudse, J G & Zeeman, G G 2016, ' Cerebral white matter lesions, subjective cognitive failures, and objective neurocognitive functioning : A follow-up study in women after hypertensive disorders of pregnancy ', Journal of Clinical and Experimental Neuropsychology, vol. 38, no. 5, pp. 585-598 . https://doi.org/10.1080/13803395.2016.1143453, Journal of Clinical and Experimental Neuropsychology, 38(5), 585-598. Taylor and Francis Ltd.
- Accession number :
- edsair.doi.dedup.....5696f333c7f81cfb9dc82bf6a8b0678d