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Disturbed mitochondrial redox state and tissue energy charge in cholestasis

Authors :
Zhipeng Jia
Reza Heidari
Omid Farshad
Vahid Ghanbarinejad
Akram Jamshidzadeh
Mohammad Mehdi Ommati
Source :
Journal of biochemical and molecular toxicologyREFERENCES. 35(9)
Publication Year :
2021

Abstract

The liver is the primary organ affected by cholestasis. However, the brain, skeletal muscle, heart, and kidney are also severely influenced by cholestasis/cirrhosis. However, little is known about the molecular mechanisms of organ injury in cholestasis. The current study was designed to evaluate the mitochondrial glutathione redox state as a significant index in cell death. Moreover, tissue energy charge (EC) was calculated. Rats underwent bile duct ligation (BDL) and the brain, heart, liver, kidney, and skeletal muscle mitochondria were assessed at scheduled time intervals (3, 7, 14, and 28 days after BDL). A significant decrease in mitochondrial glutathione redox state and EC was detected in BDL animals. Moreover, disturbed mitochondrial indices were evident in different organs of BDL rats. These data could offer new insight into the mechanisms of organ injury and the source of oxidative stress during cholestasis and might provide novel therapeutic strategies against these complications.

Details

ISSN :
10990461
Volume :
35
Issue :
9
Database :
OpenAIRE
Journal :
Journal of biochemical and molecular toxicologyREFERENCES
Accession number :
edsair.doi.dedup.....5686bf258b93f49c0b00c95a92a68497