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Disturbed mitochondrial redox state and tissue energy charge in cholestasis
- Source :
- Journal of biochemical and molecular toxicologyREFERENCES. 35(9)
- Publication Year :
- 2021
-
Abstract
- The liver is the primary organ affected by cholestasis. However, the brain, skeletal muscle, heart, and kidney are also severely influenced by cholestasis/cirrhosis. However, little is known about the molecular mechanisms of organ injury in cholestasis. The current study was designed to evaluate the mitochondrial glutathione redox state as a significant index in cell death. Moreover, tissue energy charge (EC) was calculated. Rats underwent bile duct ligation (BDL) and the brain, heart, liver, kidney, and skeletal muscle mitochondria were assessed at scheduled time intervals (3, 7, 14, and 28 days after BDL). A significant decrease in mitochondrial glutathione redox state and EC was detected in BDL animals. Moreover, disturbed mitochondrial indices were evident in different organs of BDL rats. These data could offer new insight into the mechanisms of organ injury and the source of oxidative stress during cholestasis and might provide novel therapeutic strategies against these complications.
- Subjects :
- Male
medicine.medical_specialty
Cirrhosis
Bioenergetics
Health, Toxicology and Mutagenesis
Mitochondrial redox
Mitochondria, Liver
Toxicology
medicine.disease_cause
Biochemistry
Rats, Sprague-Dawley
Cholestasis
Internal medicine
medicine
Animals
Energy charge
Molecular Biology
Kidney
business.industry
Skeletal muscle
General Medicine
medicine.disease
Mitochondria, Muscle
Rats
Disease Models, Animal
medicine.anatomical_structure
Endocrinology
Organ Specificity
Molecular Medicine
business
Energy Metabolism
Oxidation-Reduction
Oxidative stress
Subjects
Details
- ISSN :
- 10990461
- Volume :
- 35
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of biochemical and molecular toxicologyREFERENCES
- Accession number :
- edsair.doi.dedup.....5686bf258b93f49c0b00c95a92a68497