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GWAS of epigenetic aging rates in blood reveals a critical role for TERT
- Source :
- Nature Communications, Nature communications, vol 9, iss 1, Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018), Lu, A T, Xue, L, Salfati, E L, Chen, B H, Ferrucci, L, Levy, D, Joehanes, R, Murabito, J M, Kiel, D P, Tsai, P-C, Yet, I, Bell, J T, Mangino, M, Tanaka, T, Mcrae, A F, Marioni, R E, Visscher, P M, Wray, N R, Deary, I J, Levine, M E, Quach, A, Assimes, T L, Tsao, P S, Absher, D, Stewart, J D, Li, Y, Reiner, A P, Hou, L, Baccarelli, A A, Whitsel, E A, Aviv, A, Cardona, A, Day, F R, Wareham, N J, Perry, J R B, Ong, K K, Raj, K, Lunetta, K L & Horvath, S 2018, ' GWAS of epigenetic aging rates in blood reveals a critical role for TERT ', Nature Communications, vol. 9, no. 1, 387 . https://doi.org/10.1038/s41467-017-02697-5
- Publication Year :
- 2017
-
Abstract
- DNA methylation age is an accurate biomarker of chronological age and predicts lifespan, but its underlying molecular mechanisms are unknown. In this genome-wide association study of 9907 individuals, we find gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration (EEAA). Mendelian randomization analysis suggests causal influences of menarche and menopause on IEAA and lipoproteins on IEAA and EEAA. Variants associated with longer leukocyte telomere length (LTL) in the telomerase reverse transcriptase gene (TERT) paradoxically confer higher IEAA (P<br />Epigenetic clocks based on DNA methylation levels are estimators of chronological age. Here, the authors perform a GWAS of epigenetic aging rates in blood and find SNP variants in the TERT locus associated with increased intrinsic epigenetic age are also associated with longer telomeres.
- Subjects :
- 0301 basic medicine
Male
Telomerase
Aging
General Physics and Astronomy
Genome-wide association study
Epigenesis, Genetic
80 and over
Leukocytes
2.1 Biological and endogenous factors
Aetiology
lcsh:Science
Child
Cells, Cultured
Genetics
Aged, 80 and over
Multidisciplinary
Cultured
Mendelian Randomization Analysis
Middle Aged
Telomere
DNA methylation
Female
Menopause
Adult
Adolescent
Science
Cells
and over
Biology
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
Young Adult
Genetic
Humans
Telomerase reverse transcriptase
Epigenetics
Gene
Aged
Menarche
Human Genome
General Chemistry
DNA Methylation
Fibroblasts
030104 developmental biology
lcsh:Q
CpG Islands
Generic health relevance
Epigenesis
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature communications
- Accession number :
- edsair.doi.dedup.....56840d378bc73cbae5c2eefbadddec46