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Investigating the synergistic mechanism between ibrutinib and daunorubicin in acute myeloid leukemia cells
- Source :
- Leukemia & Lymphoma. 57:2432-2436
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Bruton’s tyrosine kinase (BTK) is a potential therapeutic target in acute myeloid leukemia (AML) and the small molecule BTK inhibitor ibrutinib has been found to potentiate the cytotoxic activity o...
- Subjects :
- 0301 basic medicine
Cancer Research
Daunorubicin
Synergistic mechanism
03 medical and health sciences
chemistry.chemical_compound
Piperidines
immune system diseases
hemic and lymphatic diseases
medicine
Bruton's tyrosine kinase
Cytotoxic T cell
biology
Adenine
Cytarabine
Myeloid leukemia
Hematology
Small molecule
Leukemia, Myeloid, Acute
Pyrimidines
030104 developmental biology
Oncology
chemistry
Ibrutinib
biology.protein
Cancer research
Pyrazoles
Tyrosine kinase
medicine.drug
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....567c6740bbfa2ed54329fe153ab5ba90