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Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway
- Source :
- Basicclinical pharmacologytoxicology. 102(6)
- Publication Year :
- 2008
-
Abstract
- Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its anti-proliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor, and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the anti-proliferative activity of norsolorinic acid in MCF-7 cells.
- Subjects :
- medicine.medical_specialty
Fas Ligand Protein
Anthraquinones
Apoptosis
Breast Neoplasms
Adenocarcinoma
Toxicology
Fas ligand
Article
Aspergillus nidulans
Internal medicine
Cell Line, Tumor
medicine
Biomarkers, Tumor
Humans
fas Receptor
Receptor
skin and connective tissue diseases
Cell Proliferation
Pharmacology
biology
Cell growth
Plant Extracts
Cell Cycle
General Medicine
Cell cycle
biology.organism_classification
Molecular biology
Antineoplastic Agents, Phytogenic
Endocrinology
Aspergillus
MCF-7
Cell culture
Female
Drug Screening Assays, Antitumor
Subjects
Details
- ISSN :
- 17427843
- Volume :
- 102
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Basicclinical pharmacologytoxicology
- Accession number :
- edsair.doi.dedup.....5659c41cf543645d676797a667c1c46c