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Molecular mechanisms and potentials for differentiating inner ear stem cells into sensory hair cells
- Source :
- Developmental Biology. 390(2):93-101
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- In mammals, hair cells may be damaged or lost due to genetic mutation, infectious disease, chemical ototoxicity, noise and other factors, causing permanent sensorineural deafness. Regeneration of hair cells is a basic pre-requisite for recovery of hearing in deaf animals. The inner ear stem cells in the organ of Corti and vestibular utricle are the most ideal precursors for regeneration of inner ear hair cells. This review highlights some recent findings concerning the proliferation and differentiation of inner ear stem cells. The differentiation of inner ear stem cells into hair cells involves a series of signaling pathways and regulatory factors. This paper offers a comprehensive analysis of the related studies.
- Subjects :
- Biology
Notch signaling pathway
Mice
Ototoxicity
Utricle
Inner ear
Basic Helix-Loop-Helix Transcription Factors
otorhinolaryngologic diseases
medicine
Animals
Regeneration
Molecular Biology
Vestibular system
Stem cell
Receptors, Notch
Atoh1
Stem Cells
Hair Cells, Ampulla
Cell Differentiation
Anatomy
Cell Biology
Kinocilium
medicine.disease
Cell biology
medicine.anatomical_structure
Organ of Corti
Ear, Inner
sense organs
Hair cell
Signal Transduction
Developmental Biology
Subjects
Details
- ISSN :
- 00121606
- Volume :
- 390
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Developmental Biology
- Accession number :
- edsair.doi.dedup.....565811cfb820a7778ab492c9d4bc33a7
- Full Text :
- https://doi.org/10.1016/j.ydbio.2014.03.010