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Summary of clinical trials of inactivated influenza vaccine - 1978
- Source :
- Reviews of infectious diseases. 5(4)
- Publication Year :
- 1983
-
Abstract
- This report summarizes the clinical trials of the A/USSR/77 (H1N1) influenza vaccines performed in 1978. A total of 2,091 subjects participated in these trials. The results of these clinical trials indicated that two doses of H1N1 viral antigen were necessary to produce serum titers of hemagglutinin-inhibiting (HAI) antibody of greater than 1:40 in 80% or more of the test subjects younger than 25 years of age, who were unlikely to have experienced natural infection during the earlier period of prevalence of H1N1 virus (1947-1957). Only one dose of the A/Texas/77 (H3N2) or B/Hong Kong/72 antigen was necessary to stimulate equivalent titers of HAI antibody in serum. Thus, previous natural exposure to H1N1 viruses primed individuals 26 years of age or older to respond to H1N1 antigens. No major differences in antigenicity were noted between whole-virus and split-virus vaccines. No differences in reaction indexes measuring systemic reactions were noted when vaccine types were compared. Only one vaccine was associated with a reaction index appreciably higher than that of placebo. The relatively uniform antibody responses observed were attributed to the newer methods of vaccine standardization introduced after the clinical trials in 1976. No cases of vaccine-related neurological problems, including Guillain-Barre syndrome, were found during these trials. Vaccines containing 7-21 micrograms of each viral antigen were antigenic and were well tolerated.
- Subjects :
- Microbiology (medical)
Adult
Male
Adolescent
Influenza vaccine
viruses
Placebo
Antigen
Surveys and Questionnaires
Medicine
Humans
Child
Hemagglutination, Viral
Clinical Trials as Topic
biology
business.industry
Infant, Newborn
virus diseases
Infant
Hemagglutination Inhibition Tests
Middle Aged
Vaccination
Clinical trial
Titer
Infectious Diseases
Influenza Vaccines
Child, Preschool
Immunology
biology.protein
Female
Viral disease
Antibody
business
Subjects
Details
- ISSN :
- 01620886
- Volume :
- 5
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Reviews of infectious diseases
- Accession number :
- edsair.doi.dedup.....564cde03c8583666838c422a9f5f85f0