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Hypo-fractionated stereotactic radiation therapy for lung malignancies by means of helical tomotherapy: report of feasibility by a single-center experience
- Publication Year :
- 2018
-
Abstract
- Background: Several experiences in the literature report SBRT as an effective treatment option for medically inoperable early stage non-small cell lung cancer (NSCLC) and oligometastatic disease. The optimal fractionation schedules and total dose remain controversial. In this study, we evaluated the safety in terms of toxicity and efficacy of using of 8â10 fractions schedules with Helical Tomotherapy (HT) for primary and metastatic lung lesions. Methods: Between March 2014 and May 2016, a total of 39 patients (median age 72 years, range 26â91) were treated with HT-SBRT for malignant lung lesions: 22 patients with early stage NSCLC, 17 with oligometastases. Patients received 8â10 fractions with lower daily dose for central and ultracentral lesions. Treatment-related toxicity was evaluated using CTCAE v 4.0 scale. Local control (LC), overall survival (OS) and toxicity rates were prospectively collected. Results: Median duration of RT was 15 days (range 10â26 days) and no interruption occurred. With a median follow-up of 13 months (range 3â29), we reported one G2 pneumonitis (2.6%) and one G2 chest pain (2.6%); no ⥠G2 esophagitis was registered. Actuarial local control rate was 95.5% both at 12 and 24 months for early stage NSCLC and 92.9% both at 12 and 24 months for metastatic patients. OS rate was 94.4 and 92.3% at 1 year, and 94.4 and 83.9% at 2 years in primary and metastatic group, respectively. Conclusions: The use of 8â10 fractions schedule HT-SBRT for lung malignancies results in high LC and OS rates with minimal toxicities reported.
- Subjects :
- Adult
Male
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Stereotactic radiation therapy
Radiosurgery
Single Center
Tomotherapy
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Helical tomotherapy
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Radiology, Nuclear Medicine and imaging
Stage (cooking)
Lung cancer
Aged
Pneumonitis
Aged, 80 and over
SBRT
Radiotherapy
business.industry
Radiotherapy Dosage
General Medicine
Middle Aged
medicine.disease
Survival Rate
Radiation therapy
Treatment Outcome
030220 oncology & carcinogenesis
Feasibility Studies
Female
Dose Fractionation, Radiation
Radiology
business
Tomography, Spiral Computed
Esophagitis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....56452add486f1e74ab47dc833ddd7e81