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Radiomic analysis of planning computed tomograms for predicting radiation-induced lung injury and outcome in lung cancer patients treated with robotic stereotactic body radiation therapy
- Source :
- Strahlentherapie und Onkologie. 195:830-842
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- To predict radiation-induced lung injury and outcome in non-small cell lung cancer (NSCLC) patients treated with robotic stereotactic body radiation therapy (SBRT) from radiomic features of the primary tumor. In all, 110 patients with primary stage I/IIa NSCLC were analyzed for local control (LC), disease-free survival (DFS), overall survival (OS) and development of local lung injury up to fibrosis (LF). First-order (histogram), second-order (GLCM, Gray Level Co-occurrence Matrix) and shape-related radiomic features were determined from the unprocessed or filtered planning CT images of the gross tumor volume (GTV), subjected to LASSO (Least Absolute Shrinkage and Selection Operator) regularization and used to construct continuous and dichotomous risk scores for each endpoint. Continuous scores comprising 1–5 histogram or GLCM features had a significant (p = 0.0001–0.032) impact on all endpoints that was preserved in a multifactorial Cox regression analysis comprising additional clinical and dosimetric factors. At 36 months, LC did not differ between the dichotomous risk groups (93% vs. 85%, HR 0.892, 95%CI 0.222–3.590), while DFS (45% vs. 17%, p
- Subjects :
- Male
medicine.medical_specialty
Lung Neoplasms
Stereotactic body radiation therapy
Pulmonary Fibrosis
Lung injury
Radiosurgery
030218 nuclear medicine & medical imaging
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Robotic Surgical Procedures
Predictive Value of Tests
Fibrosis
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Radiology, Nuclear Medicine and imaging
Radiation Injuries
Lung cancer
Lung
Aged
Neoplasm Staging
Aged, 80 and over
business.industry
Proportional hazards model
Radiotherapy Planning, Computer-Assisted
Middle Aged
medicine.disease
Primary tumor
Tumor Burden
Treatment Outcome
Oncology
Radiation-induced lung injury
030220 oncology & carcinogenesis
Female
Radiology
Tomography
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 1439099X and 01797158
- Volume :
- 195
- Database :
- OpenAIRE
- Journal :
- Strahlentherapie und Onkologie
- Accession number :
- edsair.doi.dedup.....563cf5bfb350fc435d002399902eb476