Back to Search
Start Over
Polymerisation-Induced Self-Assembly (PISA) as a straightforward formulation strategy for Stimuli-Responsive Drug Delivery Systems and Biomaterials: Recent Advances
- Source :
- Biomaterials Science, Biomaterials Science, Royal Society of Chemistry (RSC), 2020, 9, pp.38-50. ⟨10.1039/D0BM01406K⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, the presence of redox agents, or temperature. The formulation of amphiphilic block copolymers into polymeric drug-loaded nanoparticles is typically achieved by various methods (e.g. oil-in-water emulsion solvent evaporation, solid dispersion, microphase separation, dialysis or microfluidic). Despite the several progresses that have been made, there remain many challenges to overcome to produce reliable polymeric systems. The main weakness of the above methods is that they imply very low solid contents (< 1 wt%) and multiple-step procedures, thus limiting their scope. Recently, a new self-assembly methodology, polymerisation-induced self-assembly (PISA), has shown great promise in the production of polymer-derived particles in a straightforward one-pot approach, whilst facilitating high yield, scalability, and cost-effectiveness for pharmaceutical industry protocols. We therefore focus this review primarily on the most recent studies involving in the design and preparation of PISA-generated nano-objects which are responsive to specific stimuli, thus providing an insight into how PISA may become an effective formulation strategy for the preparation of precisely tailored drug delivery systems and biomaterials, while some of the current challenges, conundrum, and limitations are also critically discussed.
- Subjects :
- Emulsion solvent evaporation
Stimuli responsive
Polymers
Computer science
[SDV]Life Sciences [q-bio]
Microfluidics
Biomedical Engineering
review
biomedicine
Nanotechnology
02 engineering and technology
010402 general chemistry
01 natural sciences
Drug Delivery Systems
Amphiphile
phramaceutical sciences
General Materials Science
smart particles
PISA
self-assembly
[CHIM.MATE]Chemical Sciences/Material chemistry
021001 nanoscience & nanotechnology
0104 chemical sciences
Drug Liberation
[CHIM.POLY]Chemical Sciences/Polymers
Polymerization
polymerization
Drug delivery
drug delivery
Nanoparticles
Self-assembly
Nanocarriers
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 20474849
- Database :
- OpenAIRE
- Journal :
- Biomaterials Science, Biomaterials Science, Royal Society of Chemistry (RSC), 2020, 9, pp.38-50. ⟨10.1039/D0BM01406K⟩
- Accession number :
- edsair.doi.dedup.....5639cd33bc434589d8107c7761d6d0dc