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Etiology and pathophysiology of heart failure in people with HIV
- Source :
- Heart failure reviews. 26(3)
- Publication Year :
- 2020
-
Abstract
- HIV-associated cardiomyopathy is a well-established sequela in people infected with HIV (PHIV). Despite significant advances in HIV management through the use of highly active anti-retroviral therapy (HAART), PHIV on HAART continue to have elevated risk of cardiomyopathy and heart failure, even when accounting for known cardiovascular risk factors. This review article will explore the proposed mechanisms by which chronic HIV infection induces cardiomyopathy and heart failure in the setting of HAART. Evaluation, work-up, and management of cardiomyopathy in PHIV will also be briefly discussed. The advent of HAART has altered the pathophysiology HIV-associated cardiomyopathy from a rapidly progressive cardiomyopathy, often with pericardial involvement, into a chronic process involving inflammation and persistent immune dysregulation. With the significant decrease in AIDS-related deaths, the prevalence of cardiomyopathy and the mortality associated with heart failure in PHIV have increased. Multiple immune-related and inflammatory mechanisms have been proposed, which may provide insight into evaluation and management of cardiomyopathy in PHIV.
- Subjects :
- medicine.medical_specialty
Cardiomyopathy
Human immunodeficiency virus (HIV)
HIV Infections
030204 cardiovascular system & hematology
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Antiretroviral Therapy, Highly Active
medicine
Humans
030212 general & internal medicine
Intensive care medicine
Heart Failure
business.industry
virus diseases
Sequela
Immune dysregulation
medicine.disease
Pathophysiology
Review article
Heart failure
Etiology
Disease Progression
Cardiology and Cardiovascular Medicine
business
Cardiomyopathies
Subjects
Details
- ISSN :
- 15737322
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Heart failure reviews
- Accession number :
- edsair.doi.dedup.....561a60dde219c4cdf75be4d300f58b51