A flow-based transition-metal-catalysed hydrogenolysis strategy to facilitate peptide side-chain deprotection

Authors :: Christopher J. Gordon
Janice R. Aldrich-Wright
Maria Menti-Platten
Source :: Organicbiomolecular chemistry. 20(1)
Publication Year :: 2021
Abstract: A palladium-catalysed flow chemistry protocol to selectively mediate Nβ side-chain Cbz-lysis from extended peptide sequences in the presence of trityl, t-butyl and Nα-Fmoc protecting groups.

Subjects :: chemistry.chemical_classification
Staphylococcus aureus
Organic Chemistry
Peptide
Flow chemistry
Biochemistry
Combinatorial chemistry
Catalysis
chemistry
Flow (mathematics)
Transition metal
Hydrogenolysis
Side chain
Transition Elements
Amino Acid Sequence
Physical and Theoretical Chemistry
Peptides
Hydrogen

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