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Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus
- Source :
- Europe PubMed Central, Fuentealba, P, Klausberger, T, Karayannis, T, Suen, W Y, Huck, J, Tomioka, R, Rockland, K, Capogna, M, Studer, M, Morales, M & Somogyi, P 2010, ' Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 30, no. 5, pp. 1595-609 . https://doi.org/10.1523/JNEUROSCI.4199-09.2010
- Publication Year :
- 2010
-
Abstract
- The COUP-TFII nuclear receptor, also known as NR2F2, is expressed in the developing ventral telencephalon and modulates the tangential migration of a set of subpallial neuronal progenitors during forebrain development. Little information is available about its expression patterns in the adult brain. We have identified the cell populations expressing COUP-TFII and the contribution of some of them to network activityin vivo. Expression of COUP-TFII by hippocampal pyramidal and dentate granule cells, as well as neurons in the neocortex, formed a gradient increasing from undetectable in the dorsal to very strong in the ventral sectors. In the dorsal hippocampal CA1 area, COUP-TFII was restricted to GABAergic interneurons and expressed in several, largely nonoverlapping neuronal populations. Immunoreactivity was present in calretinin-, neuronal nitric oxide synthase-, and reelin-expressing cells, as well as in subsets of cholecystokinin- or calbindin-expressing or radiatum-retrohippocampally projecting GABAergic cells, but not in parvalbumin- and/or somatostatin-expressing interneurons.In vivorecording and juxtacellular labeling of COUP-TFII-expressing cells revealed neurogliaform cells, basket cells in stratum radiatum and tachykinin-expressing radiatum dentate innervating interneurons, identified by their axodendritic distributions. They showed cell type-selective phase-locked firing to the theta rhythm but no activation during sharp wave/ripple oscillations. These basket cells in stratum radiatum and neurogliaform cells fired at the peak of theta oscillations detected extracellularly in stratum pyramidale, unlike previously reported ivy cells, which fired at the trough. The characterization of COUP-TFII-expressing neurons suggests that this developmentally important transcription factor plays cell type-specific role(s) in the adult hippocampus.
- Subjects :
- Male
Patch-Clamp Techniques
Neuroglia/metabolism
Cyclohexanecarboxylic Acids
Nerve Tissue Proteins/metabolism
Neurons/metabolism
Hippocampal formation
Hippocampus
COUP Transcription Factor II
Rats, Sprague-Dawley
Amines
gamma-Aminobutyric Acid
COUP Transcription Factor II/metabolism
Neurons
Extracellular Matrix Proteins
Neocortex
General Neuroscience
musculoskeletal, neural, and ocular physiology
Pyramidal Cells
Serine Endopeptidases
2800 General Neuroscience
Cell Adhesion Molecules, Neuronal/metabolism
medicine.anatomical_structure
Hippocampus/cytology
GABAergic
Neuroglia
Calretinin
Gabapentin
medicine.drug
Cell Adhesion Molecules, Neuronal
610 Medicine & health
Nerve Tissue Proteins
Axons/metabolism
Biology
gamma-Aminobutyric acid
Article
Extracellular Matrix Proteins/metabolism
Nerve Net/metabolism
Serine Endopeptidases/metabolism
Cell Lineage/genetics
Receptors, GABA
Interneurons
medicine
Animals
Pyramidal Cells/metabolism
Cell Lineage
10242 Brain Research Institute
Axons
Rats
Reelin Protein
nervous system
Forebrain
Receptors, GABA/metabolism
biology.protein
570 Life sciences
biology
Interneurons/metabolism
Nerve Net
Neuroscience
Parvalbumin
Subjects
Details
- ISSN :
- 15292401
- Volume :
- 30
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Accession number :
- edsair.doi.dedup.....55f6b243f588bdbe759e0449a547b96b