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Progress in Tumor-Associated Macrophages: From Bench to Bedside

Authors :
Yi Wang
Jie Wang
Yao-Xin Lin
Sheng-Lin Qiao
Hao Wang
Source :
Advanced Biosystems. 3:1800232
Publication Year :
2018
Publisher :
Wiley, 2018.

Abstract

Tumor-associated macrophages (TAMs) are of great interest in cancer immunology as they play an important role in the tumor microenvironment as cancer stromal cells recruited from circulating monocytes. TAMs are closely associated with tumor progression, including initiation, trophic growth, metabolism, angiogenesis, and metastasis; moreover, in clinical practice, their quantity can be related to poor prognosis. Fundamental and translational studies imply that TAMs are one of the most promising targets in tumor therapy. Herein, the biological origination and classification of TAMs, which correspond to their functions and differentiations, are reviewed in detail. In addition, recent basic research and clinical preprocess of TAMs in tumor immunotherapy are also discussed. Finally, the advances in the use of nanotechnology and TAMs for tumor therapy are discussed. This review focuses on the background and status of basic research and clinical significance of TAMs, points out the potential of TAMs in tumor immunological therapy, and clarifies the possibility of translation TAM-targeting therapies in medicine.

Details

ISSN :
23667478
Volume :
3
Database :
OpenAIRE
Journal :
Advanced Biosystems
Accession number :
edsair.doi.dedup.....55efb399ca221e3b2d191103f0477676