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Novel predictors of overt nephropathy in subjects with type 1 diabetes. A nested case control study from the Pittsburgh Epidemiology of Diabetes Complications cohort
- Source :
- Nephrology Dialysis Transplantation. 21:93-100
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- Background. Predictors of diabetic nephropathy are only partly known and traditional risk factors do not adequately explain disease risk. We thus examined novel risk factors for overt nephropathy (ON) in type 1 diabetes. Methods. The EDC is a prospective study of childhood-onset type 1 diabetes. When first seen (1986–1988), mean age was 28 and diabetes duration 19 years. In the subsequent 10 years, 56 of 485 subjects without ON in 1986–88 developed ON. An age, duration (±3 years), and sex-matched control was identified for 47 cases. Forty-two matched pairs had available stored plasma samples obtained prior to ON onset in cases, and complete standard risk factor data. Results. Cases had a higher baseline albumin excretion rate (AER), HbA1, pulse rate, non-HDL cholesterol, fibrinogen, small LDL and lower eGDR and LDL particle size compared to controls (all P values
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Adolescent
Antigen-Antibody Complex
Comorbidity
Kidney Function Tests
Risk Assessment
Severity of Illness Index
Nephropathy
Cohort Studies
Diabetic nephropathy
Age Distribution
Predictive Value of Tests
Reference Values
Internal medicine
Diabetes mellitus
Prevalence
medicine
Humans
Diabetic Nephropathies
Sex Distribution
Prospective cohort study
Probability
Glycated Hemoglobin
Transplantation
Type 1 diabetes
business.industry
Cholesterol, HDL
Case-control study
Cholesterol, LDL
Prognosis
medicine.disease
Diabetes Mellitus, Type 1
Endocrinology
Nephrology
Case-Control Studies
Multivariate Analysis
Nested case-control study
Female
business
Biomarkers
Cohort study
Subjects
Details
- ISSN :
- 14602385 and 09310509
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Nephrology Dialysis Transplantation
- Accession number :
- edsair.doi.dedup.....55dfb35b5baa048db8bba8a76c49573f