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Anti-cancer effects of COX-2 inhibitors and their correlation with angiogenesis and invasion in gastric cancer
- Source :
- World Journal of Gastroenterology. 10:1971
- Publication Year :
- 2004
- Publisher :
- Baishideng Publishing Group Inc., 2004.
-
Abstract
- AIM: To observe the anti-cancer effects of COX-2 inhibitors and investigate the relationship between COX-2 inhibitors and angiogenesis, infiltration or metastasis in SGC7901 cancer xenografts. METHODS: Thirty athymic mice xenograft models with human stomach cancer cell SGC7901 were established and divided randomly into 3 groups of 10 each. Sulindac, one non-specific COX inhibitor belonging to non-steroidal anti-inflammatory drugs (a series of COX inhibitors known as NSAIDs) and celecoxib, one selective COX-2 inhibitor (known as SCIs) were orally administered to mice of treatment groups. Immunohistochemistry was used to examine the expression of PCNA, CD44v6 and microvessel density (MVD). Apoptosis was detected by using TUNEL assay. RESULTS: Tumors in sulindac and celecoxib groups were significantly smaller than those in control group from the second week after drug administration (P < 0.01). In treatment group, the cell proliferation index was lower (P < 0.05) and apoptosis index was higher (P < 0.05) than those in control groups. Compared with the controls, microvessel density was reduced (P < 0.01) and expression of CD44v6 on tumor cells was weakened (P < 0.05) in treatment groups. CONCLUSION: COX-2 inhibitors have anticancer effects on gastric cancer. They play important roles in angiogenesis and infiltration or metastasis of stomach carcinoma. The anticancer effects of COX-2 inhibitors may include inducing apoptosis, suppressing proliferation, reducing angiogenesis and weakening invasiveness.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Angiogenesis
Mice, Nude
Apoptosis
Biology
Metastasis
Neovascularization
Mice
Sulindac
Stomach Neoplasms
Cell Line, Tumor
medicine
Animals
Humans
Cyclooxygenase Inhibitors
Neoplasm Invasiveness
Sulfonamides
Cyclooxygenase 2 Inhibitors
Neovascularization, Pathologic
Cell growth
Gastroenterology
Membrane Proteins
General Medicine
medicine.disease
Xenograft Model Antitumor Assays
Isoenzymes
Celecoxib
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
Cancer cell
Cancer research
Pyrazoles
Brief Reports
medicine.symptom
Cell Division
medicine.drug
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....55c864aa5429d5a86817ecadf1fb071f