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The role of the fallopian tube in the origin of ovarian cancer
- Source :
- American Journal of Obstetrics and Gynecology. 209:409-414
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Advanced cases of epithelial ovarian, primary peritoneal, and primary tubal malignancies have a relatively poor prognosis and collectively remain the most deadly of all gynecologic malignancies. Although traditionally thought of as one disease process, ongoing research suggests that there is not 1 single site or cell type from which these cancers arise. A majority of the serous tumors appear to originate from dysplastic lesions in the distal fallopian tube. Therefore, what we have traditionally considered “ovarian” cancer may in fact be tubal in origin. In this article, we will review epithelial ovarian cancer classification and genetics, theories regarding cells of origin with a focus on tubal intraepithelial carcinoma, and implications for prevention and screening.
- Subjects :
- Pathology
medicine.medical_specialty
animal structures
business.industry
Carcinoma in situ
Obstetrics and Gynecology
Cancer
medicine.disease
medicine.disease_cause
Article
female genital diseases and pregnancy complications
Serous fluid
medicine.anatomical_structure
Fallopian Tube Neoplasm
medicine
Carcinoma
Ovarian cancer
Carcinogenesis
business
Fallopian tube
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 209
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....55c107d10b61083ef3f603577499a8f2
- Full Text :
- https://doi.org/10.1016/j.ajog.2013.04.019