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The role of the fallopian tube in the origin of ovarian cancer

Authors :
Michael G. Conner
Britt K. Erickson
Charles N. Landen
Source :
American Journal of Obstetrics and Gynecology. 209:409-414
Publication Year :
2013
Publisher :
Elsevier BV, 2013.

Abstract

Advanced cases of epithelial ovarian, primary peritoneal, and primary tubal malignancies have a relatively poor prognosis and collectively remain the most deadly of all gynecologic malignancies. Although traditionally thought of as one disease process, ongoing research suggests that there is not 1 single site or cell type from which these cancers arise. A majority of the serous tumors appear to originate from dysplastic lesions in the distal fallopian tube. Therefore, what we have traditionally considered “ovarian” cancer may in fact be tubal in origin. In this article, we will review epithelial ovarian cancer classification and genetics, theories regarding cells of origin with a focus on tubal intraepithelial carcinoma, and implications for prevention and screening.

Details

ISSN :
00029378
Volume :
209
Database :
OpenAIRE
Journal :
American Journal of Obstetrics and Gynecology
Accession number :
edsair.doi.dedup.....55c107d10b61083ef3f603577499a8f2
Full Text :
https://doi.org/10.1016/j.ajog.2013.04.019