Molecular Physiology of pH-Sensitive Background K2P Channels

Authors :: Jacques Barhanin
Florian Lesage
Institut de pharmacologie moléculaire et cellulaire (IPMC)
Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS)
COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)
Université Nice Sophia Antipolis (... - 2019) (UNS)
COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)
Source :: News in Physiological Sciences, News in Physiological Sciences, American Physiological Society, 2011, 26 (6), pp.424-37. ⟨10.1152/physiol.00029.2011⟩
Publication Year :: 2011
Publisher :: American Physiological Society, 2011.
Abstract: Background K2P channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K2P channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K2P channels.

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