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Immune interference (blunting) in the context of maternal immunization with Tdap-containing vaccines: is it a class effect?
- Source :
- Expert review of vaccines. 19(4)
- Publication Year :
- 2020
-
Abstract
- Maternal immunization with reduced antigen content tetanus-diphtheria-acellular pertussis (Tdap)-containing vaccines has been recommended to prevent infant pertussis. However, maternal antibodies may interfere with infant responses to routine immunization with diphtheria-tetanus-acellular pertussis (DTaP)-containing vaccines, raising concerns of suboptimal protection after infant vaccination. We performed a narrative literature review to assess whether blunting occurs regardless of the manufacturer of maternal and infant vaccines. Because internationally agreed correlates of protection are lacking, the clinical significance of blunting is not yet fully understood. We have reviewed the evidence available to date.Thirteen studies that evaluated blunting after maternal immunization and infant primary/booster series were identified. Blunting was observed with various combinations of Tdap- and DTaP-containing vaccines for maternal and pediatric immunization. Studies assessing the effectiveness of maternal Tdap immunization beyond the primary infant immunization series in England and in the United States suggested no evidence of a clinically relevant blunting effect so far.This review indicates that the phenomenon of blunting does not depend on the manufacturer/brand of the pertussis-containing vaccines used for immunizing mothers or children. Currently, there is no epidemiological evidence that children whose mothers received Tdap are at increased risk of pertussis after pediatric vaccinations, although longer follow-up is required.
- Subjects :
- 0301 basic medicine
Immunology
Immunization, Secondary
Context (language use)
Class effect
Interference (genetic)
Diphtheria-Tetanus-acellular Pertussis Vaccines
complex mixtures
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
Pregnancy
Drug Discovery
Medicine
Humans
030212 general & internal medicine
Pharmacology
biology
business.industry
Vaccination
Infant
030104 developmental biology
Immunization
biology.protein
Molecular Medicine
Female
Antibody
business
Immunity, Maternally-Acquired
Subjects
Details
- ISSN :
- 17448395
- Volume :
- 19
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Expert review of vaccines
- Accession number :
- edsair.doi.dedup.....55bccc0e7472b494ae853087794e5f70