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An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder
- Source :
- Psychiatric Genetics. 16:133-138
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- Objective A series of methamphetamine psychosis reveals two kinds of clinical courses of methamphetamine psychosis: transient type and prolonged type. Furthermore, paranoid psychosis sometimes recurs without methamphetamine reuse, referred to as spontaneous relapse. Dysfunction of central dopaminergic neurotransmission has been implicated in the pathogenesis of these psychiatric states. Catechol-O-methyl transferase appears to play a unique role in regulating synaptic dopaminergic activity. This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states. Basic methods We examined the functional polymorphism of val 158 met (catechol-O-methyl transferase) in 143 patients with methamphetamine psychosis and 200 healthy controls in Japan. The patients were divided into subgroups by several characteristic clinical features. Main results We found a significant difference in the catechol-O-methyl transferase allele frequency between patients with spontaneous relapse and the controls (P=0.018, odds ratio=1.67). Odds ratio implied that the patients with spontaneous relapse had a nearly 1.7-fold higher rate of the low activity alleles (met) than the controls. Conclusions Our results indicate that the met allele frequency of the catechol-O-methyl transferase is associated with patients who experienced methamphetamine psychosis and spontaneous relapse, suggesting that patients with a met allele appear to be at increased risk of an adverse response to methamphetamine.
- Subjects :
- Adult
Male
Psychosis
medicine.medical_specialty
Genotype
Catechol O-Methyltransferase
Methamphetamine
Gene Frequency
Recurrence
Reference Values
Polymorphism (computer science)
Internal medicine
Genetics
medicine
Humans
Allele frequency
Biological Psychiatry
Genetics (clinical)
Aged
Polymorphism, Genetic
business.industry
Dopaminergic
Odds ratio
Middle Aged
Transferase Gene
medicine.disease
Psychiatry and Mental health
Endocrinology
Psychotic Disorders
Female
Gene polymorphism
business
medicine.drug
Subjects
Details
- ISSN :
- 09558829
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Psychiatric Genetics
- Accession number :
- edsair.doi.dedup.....55ad32fa35d8f8d51ce0a8d895aef389