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Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging
- Publication Year :
- 2018
- Publisher :
- Society of Photo-Optical Instrumentation Engineers, 2018.
-
Abstract
- Near-infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response in patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In this study, we introduce our recently developed ultrasound-guided DOT system, which has been improved in system compactness, robustness, and user-friendliness by custom-designed electronics, automated data preprocessing, and implementation of a new two-step reconstruction algorithm. The system performance has been tested with several sets of solid and blood phantoms and the results show accuracy in reconstructed absorption coefficients as well as blood oxygen saturation. A clinical example of a breast cancer patient, who was undergoing neoadjuvant chemotherapy, is given to demonstrate the system performance.
- Subjects :
- Computer science
Biomedical Engineering
Breast Neoplasms
Special Section on Translational Biophotonics
01 natural sciences
030218 nuclear medicine & medical imaging
010309 optics
Biomaterials
03 medical and health sciences
0302 clinical medicine
Breast cancer
Robustness (computer science)
0103 physical sciences
medicine
Mammography
Preprocessor
Humans
Tomography, Optical
Modality (human–computer interaction)
Spectroscopy, Near-Infrared
medicine.diagnostic_test
business.industry
Ultrasound
Reconstruction algorithm
medicine.disease
Atomic and Molecular Physics, and Optics
Diffuse optical imaging
Electronic, Optical and Magnetic Materials
Female
Ultrasonography, Mammary
business
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....55a4db589a2afb258e05c56eb2e3ff0e