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Frontal areas contribute to reduced global coordination of resting-state gamma activities in drug-naïve patients with schizophrenia
- Source :
- Schizophrenia research. 130(1-3)
- Publication Year :
- 2011
-
Abstract
- Schizophrenia has been postulated to involve impaired neuronal cooperation in large-scale neural networks, including cortico-cortical circuitry. Alterations in gamma band oscillations have attracted a great deal of interest as they appear to represent a pathophysiological process of cortical dysfunction in schizophrenia. Gamma band oscillations reflect local cortical activities, and the synchronization of these activities among spatially distributed cortical areas has been suggested to play a central role in the formation of networks. To assess global coordination across spatially distributed brain regions, Omega complexity (OC) in multichannel EEG was proposed. Using OC, we investigated global coordination of resting-state EEG activities in both gamma (30–50 Hz) and below-gamma (1.5–30 Hz) bands in drug-naive patients with schizophrenia and investigated the effects of neuroleptic treatment. We found that gamma band OC was significantly higher in drug-naive patients with schizophrenia compared to control subjects and that a right frontal electrode (F3) contributed significantly to the higher OC. After neuroleptic treatment, reductions in the contribution of frontal electrodes to global OC in both bands correlated with the improvement of schizophrenia symptomatology. The present study suggests that frontal brain processes in schizophrenia were less coordinated with activity in the remaining brain. In addition, beneficial effects of neuroleptic treatment were accompanied by improvement of brain coordination predominantly due to changes in frontal regions. Our study provides new evidence of improper intrinsic brain integration in schizophrenia by investigating the resting-state gamma band activity.
- Subjects :
- Adult
Male
Adolescent
Rest
Electroencephalography
Statistics, Nonparametric
Young Adult
medicine
Humans
Gamma band oscillations
Beneficial effects
Biological Psychiatry
Brain Mapping
Resting state fMRI
medicine.diagnostic_test
Middle Aged
medicine.disease
Control subjects
Risperidone
Brain Waves
Frontal Lobe
Psychiatry and Mental health
Drug-naïve
Schizophrenia
Female
Psychology
Neuroscience
Gamma band
medicine.drug
Antipsychotic Agents
Follow-Up Studies
Subjects
Details
- ISSN :
- 15732509
- Volume :
- 130
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- Schizophrenia research
- Accession number :
- edsair.doi.dedup.....55867253ed55b1fa233f4d787540534f