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Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation
- Source :
- Bioscience Reports
- Publication Year :
- 2020
- Publisher :
- Portland Press Ltd., 2020.
-
Abstract
- Iron stores at birth are essential to meet iron needs during the first 4–6 months of life. The present study aimed to investigate iron stores in normal birth weight, healthy, term neonates. Umbilical cord blood samples were collected from apparently normal singleton vaginal deliveries (n=854). Subjects were screened and excluded if C-reactive protein (CRP) > 5 mg/l or α1-acid glycoprotein (AGP) > 1 g/l, preterm ( 4000g. In total, 762 samples were included in the study. Serum ferritin, soluble transferrin receptor (sTfR), hepcidin, and erythropoietin (EPO) were measured in umbilical cord blood samples; total body iron (TBI) (mg/kg) was calculated using sTfR and ferritin concentrations. A total of 19.8% newborns were iron deficient (ferritin 35 μg/l) and an additional 46.6% had insufficient iron stores (ferritin < 76 μg/l). There was a positive association between serum ferritin and sTfR, hepcidin, and EPO. Gestational age was positively associated with ferritin, sTfR, EPO, and hepcidin. In conclusion, we demonstrate a high prevalence of insufficient iron stores in a Chinese birth cohort. The value of cord sTfR and TBI in the assessment of iron status in the newborn is questionable, and reference ranges need to be established.
- Subjects :
- 0301 basic medicine
Physiology
Biochemistry
Umbilical cord
Molecular Bases of Health & Disease
0302 clinical medicine
Pregnancy
Birth Weight
Medicine
Research Articles
030219 obstetrics & reproductive medicine
biology
Gestational age
Iron Deficiencies
Orosomucoid
Fetal Blood
C-Reactive Protein
medicine.anatomical_structure
Cord blood
cord blood
Female
Inflammation Mediators
Cordocentesis
Adult
Iron
Birth weight
Biophysics
Gestational Age
03 medical and health sciences
Hepcidins
Hepcidin
Receptors, Transferrin
Humans
Erythropoietin
Molecular Biology
soluble transferrin receptor
Soluble transferrin receptor
Full Term
Inflammation
iron stores
030109 nutrition & dietetics
business.industry
ferritin
Infant, Newborn
Cell Biology
neonates
Ferritin
Metabolism
Ferritins
biology.protein
business
Biomarkers
Developmental Biology
Subjects
Details
- ISSN :
- 15734935 and 01448463
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....5586234aba0eff08b94767fe635db830