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Blood pressure changes after renal denervation are more pronounced in women and nondiabetic patients
- Source :
- Journal of Hypertension. 37:2290-2297
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Three recently published sham-controlled studies proved the efficacy of renal denervation (RDN) in hypertensive patients. The study presented here analyzed a nationwide multicentre registry database to clarify which patient subgroups benefit most from radiofrequency RDN.This is a post hoc analysis from the multicentre Austrian Transcatheter Renal Denervation Registry hosted by the Austrian Society of Hypertension. We correlated change of SBP after RDN to sex and presence/absence of comorbidities. Univariable correlation and multiple linear regression analyses were performed.Two hundred and ninety-one patients (43% women, median age 64 years) undergoing RDN between April 2011 and September 2014 were included in this analysis. Mean baseline ambulatory 24 h BP (systolic/diastolic) was 150 ± 18/89 ± 14 mmHg and mean baseline office BP was 170 ± 16/94 ± 14 mmHg.After RDN, mean ambulatory 24 h BP reduction was 9 ± 19/6 ± 16 mmHg. The following features were associated with a good response to RDN: high baseline systolic ambulatory BP, high baseline diastolic office BP, female sex, absence of diabetes mellitus, and absence of peripheral artery disease. Multivariable analysis identified female sex and absence of diabetes mellitus as strongest predictors for ambulatory BP reduction, although those groups had the lowest baseline ambulatory BP.Ambulatory BP reductions after RDN were substantially more pronounced in female and in nondiabetic patients despite lower baseline BP. It is concluded that in terms of efficacy female patients and nondiabetic patients might benefit more from RDN.
- Subjects :
- Male
medicine.medical_specialty
Physiology
Treatment outcome
Patient subgroups
MEDLINE
Blood Pressure
030204 cardiovascular system & hematology
Kidney
03 medical and health sciences
Renal Artery
0302 clinical medicine
Internal medicine
Internal Medicine
medicine
Humans
Registries
030212 general & internal medicine
Aged
Denervation
business.industry
Blood Pressure Determination
Middle Aged
Treatment Outcome
medicine.anatomical_structure
Blood pressure
Multicenter study
Austria
Hypertension
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 02636352
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Journal of Hypertension
- Accession number :
- edsair.doi.dedup.....5584b7ef45bcb1f264aaa918cf3546b4