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GABA levels are differentially associated with bimanual motor performance in older as compared to young adults
- Source :
- NeuroImage, NeuroImage, Vol 231, Iss, Pp 117871-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Although gamma aminobutyric acid (GABA) is of particular importance for efficient motor functioning, very little is known about the relationship between regional GABA levels and motor performance. Some studies sug- gest this relation to be subject to age-related differences even though literature is scarce. To clarify this matter, we employed a comprehensive approach and investigated GABA levels within young and older adults across multiple motor tasks as well as multiple brain regions. Specifically, 30 young and 30 older adults completed a task battery of three different bimanual tasks. Furthermore, GABA levels were obtained within bilateral primary sensorimotor cortex (SM1), bilateral dorsal premotor cortex, the supplementary motor area and bilateral dorso- lateral prefrontal cortex (DLPFC) using magnetic resonance spectroscopy. Results indicated that older adults, as compared to their younger counterparts, performed worse on all bimanual tasks and exhibited lower GABA levels in bilateral SM1 only. Moreover, GABA levels across the motor network and DLPFC were differentially associated with performance in young as opposed to older adults on a manual dexterity and bimanual coordination task but not a finger tapping task. Specifically, whereas higher GABA levels related to better manual dexterity within older adults, higher GABA levels predicted poorer bimanual coordination performance in young adults. By de- termining a task-specific and age-dependent association between GABA levels across the cortical motor network and performance on distinct bimanual tasks, the current study advances insights in the role of GABA for motor performance in the context of aging. ispartof: Neuroimage vol:231 issue:May 2021 ispartof: location:United States status: published
- Subjects :
- Adult
Male
medicine.medical_specialty
Aging
MRS
Magnetic Resonance Spectroscopy
Cognitive Neuroscience
Movement
Neurosciences. Biological psychiatry. Neuropsychiatry
Context (language use)
Audiology
050105 experimental psychology
gamma-Aminobutyric acid
Article
Functional Laterality
Premotor cortex
03 medical and health sciences
Young Adult
GABA
Motor performance
0302 clinical medicine
medicine
Humans
0501 psychology and cognitive sciences
Young adult
Association (psychology)
gamma-Aminobutyric Acid
Aged
Supplementary motor area
business.industry
05 social sciences
Brain
Middle Aged
Dorsolateral prefrontal cortex
medicine.anatomical_structure
Neurology
nervous system
Finger tapping
Female
business
030217 neurology & neurosurgery
Psychomotor Performance
RC321-571
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- NeuroImage, NeuroImage, Vol 231, Iss, Pp 117871-(2021)
- Accession number :
- edsair.doi.dedup.....555fc7eefd5e007ed6882dd5cf9d9ae5