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The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal
- Source :
- UVaDOC. Repositorio Documental de la Universidad de Valladolid, instname
- Publication Year :
- 2015
-
Abstract
- Producción Científica<br />GASH:Sal hamster strain and the control Syrian hamsters. The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic–clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem. The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
AFLP
Hamster
Audiogenic seizure
Epilepsy, Reflex
03 medical and health sciences
Behavioral Neuroscience
Epilepsy
0302 clinical medicine
Reflex Epilepsy
Seizures
Internal medicine
Cricetinae
parasitic diseases
medicine
Animals
Epilepsia audiogénica
Amplified Fragment Length Polymorphism Analysis
biology
Mesocricetus
Stupor
biology.organism_classification
medicine.disease
Disease Models, Animal
030104 developmental biology
Endocrinology
Neurology
Paroxysmal dystonia
Acoustic Stimulation
Hamsters
Neurology (clinical)
Brainstem
medicine.symptom
Psychology
Neuroscience
030217 neurology & neurosurgery
Brain Stem
Subjects
Details
- ISSN :
- 15255069
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Epilepsybehavior : EB
- Accession number :
- edsair.doi.dedup.....5556195570299844712fdc967c2946e8