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Lnc <scp>RNA</scp> ‐ <scp>ATB</scp> : An indispensable cancer‐related long noncoding <scp>RNA</scp>

Authors :
Wangyang Zheng
Jinglin Li
Zhidong Wang
Xinheng Li
Zhenglong Li
Yunfu Cui
Xingming Jiang
Source :
Cell Proliferation. 50
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Objectives Long non-coding RNAs (lncRNAs) are a group of non-protein-coding RNAs that are greater than 200 nucleotides in length. Increasing evidence indicates that lncRNAs, which may serve as either oncogenes or tumour suppressor genes, play a vital role in the pathophysiology of human diseases, especially in tumourigenesis and progression. Deregulation of lncRNAs impacts different cellular processes, such as proliferation, dedifferentiation, migration, invasion and anti-apoptosis. The aim of this review was to explore the molecular mechanism and clinical significance of long non-coding RNA-activated by transforming growth factor β (lncRNA-ATB) in various types of cancers. Materials and methods In this review, we summarize and analyze current studies concerning the biological functions and mechanisms of lncRNA-ATB in tumour development. The related studies were obtained through a systematic search of Pubmed, Web of Science, Embase and Cochrane Library. Results Long non-coding RNAs-ATB is a novel cancer-related lncRNA that was recently found to exhibit aberrant expression in a variety of malignancies, including hepatocellular carcinoma, colorectal cancer, gastric cancer, and lung cancer. Dysregulation of lncRNA-ATB has been shown to contribute to proliferation, migration and invasion of cancer cells. Long non-coding RNAs-ATB promotes tumourigenesis and progression mainly through competitively binding miRNAs to induce epithelial-mesenchymal transition (EMT). Conclusions Long non-coding RNAs-ATB likely represents a feasible cancer biomarker or therapeutic target.

Details

ISSN :
13652184 and 09607722
Volume :
50
Database :
OpenAIRE
Journal :
Cell Proliferation
Accession number :
edsair.doi.dedup.....553ac2366058b3b7b8abe96a60f7bfde
Full Text :
https://doi.org/10.1111/cpr.12381