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A genome-wide linkage analysis of dementia in the Amish
- Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :160-166
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Susceptibility genes for Alzheimer's disease are proving to be highly challenging to detect and verify. Population heterogeneity may be a significant confounding factor contributing to this difficulty. To increase the power for disease susceptibility gene detection, we conducted a genome-wide genetic linkage screen using individuals from the relatively isolated, genetically homogeneous, Amish population. Our genome linkage analysis used a 407-microsatellite-marker map (average density 7 cM) to search for autosomal genes linked to dementia in five Amish families from four Midwestern U.S. counties. Our highest two-point lod score (3.01) was observed at marker D4S1548 on chromosome 4q31. Five other regions (10q22, 3q28, 11p13, 4q28, 19p13) also demonstrated suggestive linkage with markers having two-point lod scores >2.0. While two of these regions are novel (4q31 and 11p13), the other regions lie close to regions identified in previous genome scans in other populations. Our results identify regions of the genome that may harbor genes involved in a subset of dementia patients, in particular the North American Amish community.
- Subjects :
- Male
Indiana
Genotype
Genetic Linkage
Population
Biology
Genome
Article
Genetic determinism
Cellular and Molecular Neuroscience
Gene mapping
Genetic linkage
Ethnicity
Humans
education
Gene
Genetics (clinical)
Ohio
Genetics
Linkage (software)
education.field_of_study
Genome, Human
Psychiatry and Mental health
Microsatellite
Dementia
Female
Lod Score
Microsatellite Repeats
Subjects
Details
- ISSN :
- 1552485X and 15524841
- Database :
- OpenAIRE
- Journal :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Accession number :
- edsair.doi.dedup.....5539dac6167c2ccf7a7a6499b5d150ff