Back to Search
Start Over
An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS)
- Source :
- Neuropsychologia. 40:471-478
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Velo-cardio-facial syndrome (VCFS) is associated with deletions on the long arm of chromosome 22, mild intellectual disability, poor social interaction and a high prevalence of psychosis. However, to date there have been no studies investigating the neuropsychological functioning of adults with VCFS. We compared 19 adults with VCFS with 19 age, gender and IQ matched controls using a comprehensive neuropsychological battery. Compared to controls, adults with VCFS had significant impairments in visuoperceptual ability (Visual Object and Space Perception Battery), problem solving and planning (Tower of London) and abstract and social thinking (Comprehension WAIS-R). It is likely that haploinsufficiency (reduced gene dosage) of a neurodevelopmental gene or genes mapping to chromosome 22q11 underlies the cognitive deficits observed in individuals with VCFS.
- Subjects :
- Adult
Male
medicine.medical_specialty
Psychosis
Chromosomes, Human, Pair 22
Cognitive Neuroscience
Experimental and Cognitive Psychology
Neuropsychological Tests
Audiology
Craniofacial Abnormalities
Behavioral Neuroscience
Cognition
Intellectual Disability
Intellectual disability
medicine
Humans
Psychiatry
Problem Solving
medicine.diagnostic_test
Cognitive disorder
Neuropsychology
Brain
Facies
Syndrome
Neuropsychological test
Middle Aged
medicine.disease
Form Perception
Haplotypes
Psychotic Disorders
Case-Control Studies
Space Perception
Female
Chromosome Deletion
Haploinsufficiency
Psychology
Chromosome 22
Subjects
Details
- ISSN :
- 00283932
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Neuropsychologia
- Accession number :
- edsair.doi.dedup.....5538eaf332da352631c5feed325de2ec