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Cardiac resynchronization improves microcirculation

Authors :: Bektaş Atasever
Ayten Erol-Yilmaz
Keshen R. Mathura
Raymond Tukkie
Can Ince
Arthur A.M. Wilde
Jerome A. Lindeboom
Biomedical Engineering and Physics
Other Research
Oral and Maxillofacial Surgery
Amsterdam Cardiovascular Sciences
Cardiology
Translational Physiology
MKA (OUD, ACTA)
Source :: Erol-Yılmaz, A, Atasever, B, Mathura, K R, Lindeboom, J A H, Wilde, A, İnce, C & Tukkie, R 2007, ' Cardiac resynchronization improves microcirculation ', Journal of Cardiac Failure, vol. 13, pp. 95-99 . https://doi.org/10.1016/j.cardfail.2006.10.016, Journal of cardiac failure, 13(2), 95-99. Churchill Livingstone, Journal of cardiac failure, 13, 95-99. Churchill Livingstone, Journal of Cardiac Failure, 13, 95-99. Churchill Livingstone
Publication Year :: 2007
Publisher :: Churchill Livingstone, 2007.
Abstract: Background: Although it is known that cardiac resynchronization therapy (CRT) in heart failure (HE) patients improves systemic circulation, its acute effects oil microcirculation are as yet unknown. Therefore we investigated the sublingual microcirculatory changes in HF patients from CRT and right ventricular (RV) pacing by use of orthogonal polarization spectral (OPS) imaging. Methods and Results: Twelve consecutive HF patients with a CRT device and 20 healthy individuals (HI) were included. Acute microcirculatory changes were assessed by functional capillary density (FCD) and capillary velocity (CV) measurement 6 months after CRT. FCD and CV were measured in HE patients sublingually after 15 minutes of programming 1 of 3 pacing modalities in random order (no pacing, RV pacing, and CRT). FCD was significantly higher in HI (11.2 +/- 2.1 cm/cm(2)) compared with HE patients with RV pacing (8.9 +/- 1.9 cm/cm(2); P = .03) and no pacing (8.3 +/- 2.4 cm/cm(2); P = .02). CRT (12.1 +/- 2.2 cm/cm(2)) significantly increased FCD in HE patients compared with RV pacing (8.9 +/- 1.9 cm/cm(2) P = .006) and no pacing (8.3 +/- 2.4 cm/cm(2); P = .008). CV was normal in all patients with or without pacing. Conclusions: CRT improves microcirculatory function as assessed by OPS imaging