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An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer
- Source :
- Biochemical and biophysical research communications. 528(2)
- Publication Year :
- 2019
-
Abstract
- The RNA binding proteins (RBPs) have multiple roles in human cancer. However, their molecular target and function have not been clearly identified. Our genomic analysis derived from patients reveals that NONO is a potential oncogenic gene in lung cancer. NONO is highly expressed in lung cancer tissues compared with normal tissues, and its expression has been correlated with the prognosis of lung cancer patients. We found that NONO significantly influences cancer cell proliferation in lung cancer. Gene expression profiles with NONO-depleted cells revealed that the sirtuin signaling pathway is highly correlated with NONO. Thus, NONO-silenced cells caused reduction of the TCA cycle and glycolysis metabolism. We identified that NONO regulated NAMPT, which is a well-known gene involved in sirtuin signaling, and NONO has a significant correlation with NAMPT in lung cancer patients. We propose that NONO modulates energy metabolism by direct interaction with NAMPT and suggest that a functional relationship between NONO and NAMPT contributes to lung cancer cell survival. Targeting the axis can be a promising approach for patient treatment in lung cancer.
- Subjects :
- 0301 basic medicine
Lung Neoplasms
Biophysics
RNA-binding protein
Biochemistry
03 medical and health sciences
0302 clinical medicine
Cell Line, Tumor
Gene expression
medicine
Humans
Glycolysis
Lung cancer
Nicotinamide Phosphoribosyltransferase
Molecular Biology
Gene
Cell Proliferation
biology
RNA-Binding Proteins
Cell Biology
medicine.disease
Citric acid cycle
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
030104 developmental biology
030220 oncology & carcinogenesis
Sirtuin
biology.protein
Cancer research
Cytokines
Signal transduction
Energy Metabolism
Subjects
Details
- ISSN :
- 10902104
- Volume :
- 528
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....552b7a455f790897445d936391d84753