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Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells
- Source :
- The journal of physiological sciences : JPS. 64(3)
- Publication Year :
- 2014
-
Abstract
- Hyperthermia is a promising anti-cancer treatment in which the tissue temperature is increased to 42-45 °C, and which is often used in combination with chemotherapy or radiation therapy. Our aim in the present work was to examine the feasibility of combination therapy for oral cancer with cisplatin and hyperthermia generated with ferucarbotran (Resovist(®); superparamagnetic iron oxide) in an alternating magnetic field (AMF). First, we established that administration of ferucarbotran at the approved dosage for magnetic resonance imaging provides an iron concentration sufficient to increase the temperature to 42.5 °C upon exposure to AMF. Then, we examined the effect of cisplatin combined with ferucarbotran/AMF-induced hyperthermia on cultured human oral cancer cells (HSC-3 and OSC-19). Cisplatin alone induced apoptosis of cancer cells in a dose-dependent manner, as is well known. However, the combination of cisplatin with ferucarbotran/AMF was significantly more effective than cisplatin alone. This result suggests that it might be possible to reduce the clinically effective dosage of cisplatin by administering it in combination with ferucarbotran/AMF-induced hyperthermia, thereby potentially reducing the incidence of serious cisplatin-related side effects. Further work seems justified to evaluate simultaneous thermo-chemotherapy as a new approach to anticancer therapy.
- Subjects :
- Hyperthermia
Pathology
medicine.medical_specialty
Time Factors
Combination therapy
Physiology
medicine.medical_treatment
Antineoplastic Agents
Apoptosis
Cell Line, Tumor
medicine
Humans
Magnetite Nanoparticles
Cisplatin
Chemotherapy
Dose-Response Relationship, Drug
business.industry
Squamous Cell Carcinoma of Head and Neck
Cancer
Dextrans
Hyperthermia, Induced
medicine.disease
Radiation therapy
G2 Phase Cell Cycle Checkpoints
Magnetic Fields
Chemotherapy, Adjuvant
Head and Neck Neoplasms
Cancer cell
Cancer research
Carcinoma, Squamous Cell
Feasibility Studies
Mouth Neoplasms
business
Adjuvant
medicine.drug
Subjects
Details
- ISSN :
- 18806562
- Volume :
- 64
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The journal of physiological sciences : JPS
- Accession number :
- edsair.doi.dedup.....551fc5537a81f4d632e8f617d496630a