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Semantic loss marks early Alzheimer's disease-related neurodegeneration in older adults without dementia
- Source :
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020, 12 (1), pp.1-14. ⟨10.1002/dad2.12066⟩, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020), Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2020, 12 (1), pp.1-14. ⟨10.1002/dad2.12066⟩, Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- International audience; Objective: To assess progression of semantic loss in early stages of cognitive decline using semantic and letter fluency performance, and its relation with Alzheimer's disease (AD)‐specific neurodegeneration using longitudinal multimodal neuroimaging measures.Methods: Change in verbal fluency was analyzed among 2261 non‐demented individuals with a follow‐up diagnosis of no mild cognitive impairment (MCI), amnestic MCI (aMCI), non‐amnestic MCI (naMCI), or incident dementia, using linear mixed models across 4 years of follow‐up, and relations with magnetic resonance imaging (MRI; n = 1536) and 18F‐fluorodeoxyglucose brain positron emission tomography (18F‐FDG‐PET) imaging (n = 756) using linear regression models across 2 years of follow‐up.Results: Semantic fluency declined—fastest in those at higher risk for AD (apolipoprotein E [APOE] e4 carriers, Clinical Dementia Rating score of .5, aMCI, or incident dementia)—while letter fluency did not except for those with incident dementia. Lower baseline semantic fluency was associated with an increase in white matter hyperintensities and total mean cortical thinning over time, and regionally with less hippocampal volume as well as more cortical thinning and reduced 18F‐FDG‐PET uptake in the inferior parietal lobule, entorhinal cortex, isthmus cingulate, and precuneus–posterior cingulate area. In contrast, baseline letter fluency was not associated with change in total nor regional neurodegeneration. Whole‐brain neurodegeneration over time was associated with faster decline in both fluencies, while AD‐specific regions were associated with a faster rate of decline in semantic but not letter fluency.Interpretation: This study provides strong evidence of distinctive degeneration of semantic abilities early on in relation to both cognitive decline and AD‐specific neurodegeneration.
- Subjects :
- medicine.medical_specialty
Clinical Dementia Rating
Audiology
lcsh:Geriatrics
lcsh:RC346-429
03 medical and health sciences
Fluency
0302 clinical medicine
Neuroimaging
cohort studies
medicine
Brain positron emission tomography
MORPH3Eus
Dementia
Verbal fluency test
Cognitive decline
10. No inequality
lcsh:Neurology. Diseases of the nervous system
030304 developmental biology
0303 health sciences
neuroimaging
amnestic
business.industry
cognitive aging
semantic fluency
verbal fluency
biomarkers
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
letter fluency
Alzheimer's disease
medicine.disease
Hyperintensity
MCI
Psychiatry and Mental health
lcsh:RC952-954.6
VINTAGE
Cognitive & Behavioral Assessment
Neurology (clinical)
category fluency
business
Alzheimer’s disease
030217 neurology & neurosurgery
[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23528729
- Database :
- OpenAIRE
- Journal :
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020, 12 (1), pp.1-14. ⟨10.1002/dad2.12066⟩, Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020), Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2020, 12 (1), pp.1-14. ⟨10.1002/dad2.12066⟩, Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
- Accession number :
- edsair.doi.dedup.....5514925c05893ee8cafb1656e4a6bdf4
- Full Text :
- https://doi.org/10.1002/dad2.12066⟩