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Microbeam evolution: From single cell irradiation to preclinical studies
Microbeam evolution: From single cell irradiation to preclinical studies
- Source :
- Ghita, M, Fernandez-Palomo, C, Fukunaga, H, Fredericia, P M, Schettino, G, Bräuer-Krisch, E, Butterworth, K T, McMahon, S J & Prise, K M 2018, ' Microbeam evolution: From single cell irradiation to preclinical studies ', International Journal of Radiation Biology, vol. 94, no. 8, pp. 708-718 . https://doi.org/10.1080/09553002.2018.1425807, Ghita, M, Fernandez-Palomo, C, Fukunaga, H, Fredericia, P M, Schettino, G, Bräuer-Krisch, E, Butterworth, K T, McMahon, S J & Prise, K M 2018, ' Microbeam evolution: From single cell irradiation to pre-clinical studies ', International journal of radiation biology . https://doi.org/10.1080/09553002.2018.1425807
- Publication Year :
- 2018
-
Abstract
- Purpose: This review follows the development of microbeam technology from the early days of single cell irradiations, to investigations of specific cellular mechanisms and to the development of new treatment modalities in vivo. A number of microbeam applications are discussed with a focus on preclinical modalities and translation towards clinical application.Conclusions: The development of radiation microbeams has been a valuable tool for the exploration of fundamental radiobiological response mechanisms. The strength of micro-irradiation techniques lies in their ability to deliver precise doses of radiation to selected individual cells in vitro or even to target subcellular organelles. These abilities have led to the development of a range of microbeam facilities around the world allowing the delivery of precisely defined beams of charged particles, X-rays, or electrons.In addition, microbeams have acted as mechanistic probes to dissect the underlying molecular events of the DNA damage response following highly localised dose deposition. Further advances in very precise beam delivery have also enabled the transition towards new and exciting therapeutic modalities developed at synchrotrons to deliver radiotherapy using plane parallel microbeams, in Microbeam Radiotherapy (MRT).
- Subjects :
- Materials science
MRT
Cell
Intracellular Space
Cell Communication
030218 nuclear medicine & medical imaging
Translational Research, Biomedical
03 medical and health sciences
0302 clinical medicine
Microbeam
medicine
Journal Article
Animals
Radiology, Nuclear Medicine and imaging
Irradiation
Radiometry
Radiological and Ultrasound Technology
Radiobiology
equipment and supplies
Bystander effects of radiation
medicine.anatomical_structure
Treatment modality
030220 oncology & carcinogenesis
Biophysics
DNA damage
Single-Cell Analysis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Ghita, M, Fernandez-Palomo, C, Fukunaga, H, Fredericia, P M, Schettino, G, Bräuer-Krisch, E, Butterworth, K T, McMahon, S J & Prise, K M 2018, ' Microbeam evolution: From single cell irradiation to preclinical studies ', International Journal of Radiation Biology, vol. 94, no. 8, pp. 708-718 . https://doi.org/10.1080/09553002.2018.1425807, Ghita, M, Fernandez-Palomo, C, Fukunaga, H, Fredericia, P M, Schettino, G, Bräuer-Krisch, E, Butterworth, K T, McMahon, S J & Prise, K M 2018, ' Microbeam evolution: From single cell irradiation to pre-clinical studies ', International journal of radiation biology . https://doi.org/10.1080/09553002.2018.1425807
- Accession number :
- edsair.doi.dedup.....5506a80776a2449a9aea05020e60af63
- Full Text :
- https://doi.org/10.1080/09553002.2018.1425807