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Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor
- Source :
- Organic letters. 14(18)
- Publication Year :
- 2012
-
Abstract
- An enantioselective and convergent total synthesis of pladienolide B (1) is described. Pladienolide B binds to the SF3b complex of a spliceosome and inhibits mRNA splicing activity. The synthesis features an epoxide opening reaction, an asymmetric reduction of a β-keto ester, and a cross metathesis strategy for the side chain synthesis.
- Subjects :
- Spliceosome
Molecular Structure
Chemistry
Stereochemistry
Organic Chemistry
Enantioselective synthesis
Total synthesis
Epoxide
Stereoisomerism
Metathesis
Biochemistry
Article
chemistry.chemical_compound
RNA splicing
Side chain
Spliceosomes
Epoxy Compounds
Macrolides
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052
- Volume :
- 14
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Organic letters
- Accession number :
- edsair.doi.dedup.....550198db89efbe495a36bcf4197423f6